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Epigenetic Biomarker and Personalized Precision Medicine

2020-12-21 Science
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Release : 2020-12-21
Genre : Science
Kind : eBook
Book Rating : 849/5 ( reviews)

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Book Synopsis Epigenetic Biomarker and Personalized Precision Medicine by : Jiucun Wang

Download or read book Epigenetic Biomarker and Personalized Precision Medicine written by Jiucun Wang. This book was released on 2020-12-21. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Personalized Precision Medicine: Role of Epigenetic Biomarkers

2023-09-19 Medical
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Release : 2023-09-19
Genre : Medical
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Personalized Precision Medicine: Role of Epigenetic Biomarkers by : Tommy Royal

Download or read book Personalized Precision Medicine: Role of Epigenetic Biomarkers written by Tommy Royal. This book was released on 2023-09-19. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics is the study of heritable phenotype changes that do not entail changes in the DNA sequence. Epigenetic abnormalities have emerged as the most promising biomarkers for diagnosis and prognosis in the early stage of illnesses, such as cancer, autoimmune diseases and psychological disorders. A medical model in which people are divided into groups with medical decisions, practices, interventions and products being tailored to the individual patient based on their predicted response or risk of disease is referred as personalized medicine. The terms precision medicine and personalized medicine are utilized interchangeably for describing the concept. Diagnostic testing is used often in personalized medicine to determine suitable and optimal therapies based on a patient's genetic content, or other molecular or cellular analysis. Certain aspects of personalized medicine utilize genetic information, such as pharmacogenomics. With the help of genomics, proteomics and imaging techniques, molecular scale data of the patients is obtained easily. These molecular biomarkers are then used in determining the prognosis of diseases such as cancer. The readers would gain knowledge that would broaden their perspective about personalized precision medicine through this book. Also included herein is a detailed explanation of the role of epigenetic biomarkers. This book will help the readers in keeping pace with the rapid changes in this field of study.

Epigenetics in Precision Medicine

2021-11-12 Medical
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Release : 2021-11-12
Genre : Medical
Kind : eBook
Book Rating : 058/5 ( reviews)

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Book Synopsis Epigenetics in Precision Medicine by : Jose Luis Garcia-Gimenez

Download or read book Epigenetics in Precision Medicine written by Jose Luis Garcia-Gimenez. This book was released on 2021-11-12. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease. Provides a thorough grounding in epigenetics-driven precision medicine, with emphasis on developing and implementing early diagnosis and prognosis biomarkers, and supporting patient stratification Empowers researchers and clinicians to incorporate epigenetics in new disease research, drug discovery, and clinical practice Features chapter contributions from international leaders in the field

Personalized Epigenetics

2024-08-01 Science
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Release : 2024-08-01
Genre : Science
Kind : eBook
Book Rating : 030/5 ( reviews)

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Book Synopsis Personalized Epigenetics by : Trygve Tollefsbol

Download or read book Personalized Epigenetics written by Trygve Tollefsbol. This book was released on 2024-08-01. Available in PDF, EPUB and Kindle. Book excerpt: Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Includes new chapters on topics such as the limitations of personalized epigenetic variation comparisons; personalized epigenetics technologies; epigenetics of personalized nanomedicine; personalized epigenetic management of diabetes; epigenetics and chemoresistance; and personalized epigenetics and neurological disorders Covers key methodological processes that are important in personalized medicine Offers disease research case studies to provide in-depth discussion of examples of recent epigenetic research on a disease area Features topics such as forensic epigenetics, epigenetics of personalized toxicity, limitations of epigenetic variation comparisons, and nanomedicine and nutrigenomics as applied to personalized epigenetics

Clinical and Statistical Considerations in Personalized Medicine

2014-03-27 Mathematics
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Release : 2014-03-27
Genre : Mathematics
Kind : eBook
Book Rating : 873/5 ( reviews)

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Book Synopsis Clinical and Statistical Considerations in Personalized Medicine by : Claudio Carini

Download or read book Clinical and Statistical Considerations in Personalized Medicine written by Claudio Carini. This book was released on 2014-03-27. Available in PDF, EPUB and Kindle. Book excerpt: Clinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease Treatment The first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers. Improve Patient Care and Reduce Costs and Side Effects Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.

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