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Peptide-Based Drug Design

2010-11-19 Medical
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Release : 2010-11-19
Genre : Medical
Kind : eBook
Book Rating : 690/5 ( reviews)

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Book Synopsis Peptide-Based Drug Design by : Laszlo Otvos

Download or read book Peptide-Based Drug Design written by Laszlo Otvos. This book was released on 2010-11-19. Available in PDF, EPUB and Kindle. Book excerpt: Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.

Peptide Chemistry and Drug Design

2015-02-02 Medical
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Release : 2015-02-02
Genre : Medical
Kind : eBook
Book Rating : 287/5 ( reviews)

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Book Synopsis Peptide Chemistry and Drug Design by : Ben M. Dunn

Download or read book Peptide Chemistry and Drug Design written by Ben M. Dunn. This book was released on 2015-02-02. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on peptides as drugs, a growing area ofpharmaceutical research and development. It helps readers solveproblems of discovering, developing, producing, and deliveringpeptide-based drugs. • Identifies promising new areas in peptide drugdiscovery • Includes chapters on discovery from natural sources,metabolic modification, and drug delivery • Overviews separation methods and techniques foranalysis, bond formation, and purification • Offers readers both a professional reference and atext or resource for graduate-level students

Peptide-based Drug Discovery

2017-06-26 Medical
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Release : 2017-06-26
Genre : Medical
Kind : eBook
Book Rating : 324/5 ( reviews)

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Book Synopsis Peptide-based Drug Discovery by : Ved Srivastava

Download or read book Peptide-based Drug Discovery written by Ved Srivastava. This book was released on 2017-06-26. Available in PDF, EPUB and Kindle. Book excerpt: With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.

Peptide Drug Discovery and Development

2011-10-24 Medical
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Release : 2011-10-24
Genre : Medical
Kind : eBook
Book Rating : 749/5 ( reviews)

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Book Synopsis Peptide Drug Discovery and Development by : Miguel Castanho

Download or read book Peptide Drug Discovery and Development written by Miguel Castanho. This book was released on 2011-10-24. Available in PDF, EPUB and Kindle. Book excerpt: Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

Peptide Therapeutics

2022-09-26 Medical
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Release : 2022-09-26
Genre : Medical
Kind : eBook
Book Rating : 440/5 ( reviews)

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Book Synopsis Peptide Therapeutics by : Seetharama D. Jois

Download or read book Peptide Therapeutics written by Seetharama D. Jois. This book was released on 2022-09-26. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues. It covers the design concept of peptide therapeutics from fundamental principles using structural biology and computational approaches. The chapters are arranged in a linear fashion. A fresh graduate or a scientist who works on small molecules can use this to follow the design and development of peptide therapeutics to use as understanding the basic concepts. Each chapter is written by experts from academia as well as industry. Rather than covering extensive literature, the book provides concepts of design, synthesis, delivery, as well as regulatory affairs and manufacturing of peptides in a systematic way with examples in each case. The book can be used as a reference for a pharmaceutical or biomedical scientist or graduate student who wants to pursue their career in peptide therapeutics. Some chapters will be written as a combination of basic principles and protocol so that scientists can adopt these methods to their research work. The examples provided can be used to perform peptide formulation considerations for the designed peptides. The book has nine chapters, and each chapter can be read as an independent unit on a particular concept.

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