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Pathologies of Calcium Channels

2013-11-09 Medical
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Release : 2013-11-09
Genre : Medical
Kind : eBook
Book Rating : 828/5 ( reviews)

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Book Synopsis Pathologies of Calcium Channels by : Norbert Weiss

Download or read book Pathologies of Calcium Channels written by Norbert Weiss. This book was released on 2013-11-09. Available in PDF, EPUB and Kindle. Book excerpt: Calcium ions represent Mother Nature’s ‘ion-of-choice’ for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies. Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels.

Store-Operated Calcium Channels

2013-07-24 Science
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Release : 2013-07-24
Genre : Science
Kind : eBook
Book Rating : 385/5 ( reviews)

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Book Synopsis Store-Operated Calcium Channels by :

Download or read book Store-Operated Calcium Channels written by . This book was released on 2013-07-24. Available in PDF, EPUB and Kindle. Book excerpt: Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject

Calcium Channels

1991-07-03 Medical
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Release : 1991-07-03
Genre : Medical
Kind : eBook
Book Rating : 071/5 ( reviews)

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Book Synopsis Calcium Channels by : L. Donald Partridge

Download or read book Calcium Channels written by L. Donald Partridge. This book was released on 1991-07-03. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive compendium of information available on calcium channels Calcium channels are a common component of the membranes of a wide range of excitable cells, and their presence is crucial to the functioning of these cells. This book presents a current review of the biophysics, physiology, pharmacology, and clinical role of calcium channels. Chapters discussing the biophysics of calcium channels include topics in ion permeation, channel activation, channel inactivation, and second messenger modulation. The chapters on physiology cover excitation-contraction coupling, excitation-secretion coupling, sensory transduction, regulation of electrical activity, and the regulation of cell growth and development. Issues discussed in the pharmacology chapters of the book include the effects of permeant and inhibitory inorganic ions, blocking and activating effects of organic ions, and the regulatory effects of naturally occurring compounds. The chapters exploring the clinical aspects of calcium channels examine topics such as the modulation of calcium channels in the treatment of ischemic heart disease, cardiomyopathies, hypertension, cardiac arrhythmias, peripheral vascular diseases, platelet-related disorders, neurological disorders, and psychiatric disorders. Physicians neuroscientists, and pharmacologists should consider this book essential to their reference collections.

Voltage-Gated Calcium Channels

2022-11-07 Science
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Release : 2022-11-07
Genre : Science
Kind : eBook
Book Rating : 816/5 ( reviews)

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Book Synopsis Voltage-Gated Calcium Channels by : Gerald Werner Zamponi

Download or read book Voltage-Gated Calcium Channels written by Gerald Werner Zamponi. This book was released on 2022-11-07. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.

Calcium Signalling and Disease

2007-09-29 Medical
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Release : 2007-09-29
Genre : Medical
Kind : eBook
Book Rating : 919/5 ( reviews)

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Book Synopsis Calcium Signalling and Disease by : Ernesto Carafoli

Download or read book Calcium Signalling and Disease written by Ernesto Carafoli. This book was released on 2007-09-29. Available in PDF, EPUB and Kindle. Book excerpt: Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.

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