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OECD Series on Testing and Assessment The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins

2014-09-03
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Release : 2014-09-03
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Kind : eBook
Book Rating : 441/5 ( reviews)

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Book Synopsis OECD Series on Testing and Assessment The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins by : OECD

Download or read book OECD Series on Testing and Assessment The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins written by OECD. This book was released on 2014-09-03. Available in PDF, EPUB and Kindle. Book excerpt: This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies databases containing test results related to key events.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442C: In Chemico Skin Sensitisation Assays addressing the Adverse Outcome Pathway key event on covalent binding to proteins

2015-02-05
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Release : 2015-02-05
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Book Rating : 701/5 ( reviews)

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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442C: In Chemico Skin Sensitisation Assays addressing the Adverse Outcome Pathway key event on covalent binding to proteins by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442C: In Chemico Skin Sensitisation Assays addressing the Adverse Outcome Pathway key event on covalent binding to proteins written by OECD. This book was released on 2015-02-05. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. It provides an in chemico procedure (Direct Peptide Reactivity Assay – DPRA) used for supporting the discrimination between skin sensitisers and non-sensitisers.

A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment

2018-02-24 Science
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Release : 2018-02-24
Genre : Science
Kind : eBook
Book Rating : 845/5 ( reviews)

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Book Synopsis A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment by : Natàlia Garcia-Reyero

Download or read book A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment written by Natàlia Garcia-Reyero. This book was released on 2018-02-24. Available in PDF, EPUB and Kindle. Book excerpt: Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.

Alternatives to Animal Testing

2018-12-27 Medical
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Release : 2018-12-27
Genre : Medical
Kind : eBook
Book Rating : 476/5 ( reviews)

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Book Synopsis Alternatives to Animal Testing by : Hajime Kojima

Download or read book Alternatives to Animal Testing written by Hajime Kojima. This book was released on 2018-12-27. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.

Skin 3-D Models and Cosmetics Toxicity

2023-08-28 Medical
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Release : 2023-08-28
Genre : Medical
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Book Rating : 044/5 ( reviews)

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Book Synopsis Skin 3-D Models and Cosmetics Toxicity by : Aditya Bhushan Pant

Download or read book Skin 3-D Models and Cosmetics Toxicity written by Aditya Bhushan Pant. This book was released on 2023-08-28. Available in PDF, EPUB and Kindle. Book excerpt: Efforts are being made by research organizations and cosmetic industries worldwide to develop more precise and targeted 3D models that mimic humans for testing cosmetic and personal health care product ingredients, following a complete ban on animal testing. This book includes several subtopics dedicated to the progress made, challenges faced, roadblocks encountered, and future prospects in the development and validation of 3D models for testing these products. The book consist of an editorial and 14 themed chapters that will showcase the significant progress made so far, challenges encountered, and future prospects in the development of 3D reconstruct models.

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