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Author : Jeremy Copp
Release : 2003
Genre :
Kind : eBook
Book Rating : /5 ( reviews)
Book Synopsis Normal and Pathological Activation of Receptor Protein-tyrosine Kinases by : Jeremy Copp
Download or read book Normal and Pathological Activation of Receptor Protein-tyrosine Kinases written by Jeremy Copp. This book was released on 2003. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Deric L. Wheeler
Release : 2015-07-31
Genre : Science
Kind : eBook
Book Rating : 889/5 ( reviews)
Book Synopsis Receptor Tyrosine Kinases: Family and Subfamilies by : Deric L. Wheeler
Download or read book Receptor Tyrosine Kinases: Family and Subfamilies written by Deric L. Wheeler. This book was released on 2015-07-31. Available in PDF, EPUB and Kindle. Book excerpt: This book devotes a chapter to each RTK family and the multiple receptors within each family, thoroughly covering all of the RTKs. The chapters all follow the same structure, presenting this essential information in an accessible and user-friendly format. Each chapter covers one specific family of receptors and begins with a general introduction to that family and a comprehensive discussion of that receptor’s family in development and human disease. Following are in-depth analyses of each family’s receptors with discussions on the gene, protein, ligands, activation, and signaling pathways along with discussion of receptor processing and signal attenuation. Further, cross talk with other receptors systems, post-translational modification and specific unique characteristics to each RTK are discussed. Because it isolates and explains each family, this book is an essential companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, by the same authors, which talks about RTKs more generally and without the family-by-family detail.
Author :
Release : 2012-01-09
Genre : Medical
Kind : eBook
Book Rating : 872/5 ( reviews)
Book Synopsis Receptor Protein-Tyrosine Kinases: Advances in Research and Application: 2011 Edition by :
Download or read book Receptor Protein-Tyrosine Kinases: Advances in Research and Application: 2011 Edition written by . This book was released on 2012-01-09. Available in PDF, EPUB and Kindle. Book excerpt: Receptor Protein-Tyrosine Kinases: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Receptor Protein-Tyrosine Kinases. The editors have built Receptor Protein-Tyrosine Kinases: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Receptor Protein-Tyrosine Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Receptor Protein-Tyrosine Kinases: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Deric L. Wheeler
Release : 2014-11-26
Genre : Science
Kind : eBook
Book Rating : 537/5 ( reviews)
Book Synopsis Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease by : Deric L. Wheeler
Download or read book Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease written by Deric L. Wheeler. This book was released on 2014-11-26. Available in PDF, EPUB and Kindle. Book excerpt: Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family. Receptor Tyrosine Kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases. And over the last decade they have become the Number 1 targets of cancer drugs. To be able to conduct fundamental research or to attempt to develop pharmacological agents able to enhance or intercept them, it is essential first to understand the evolutionary origin of the 58 RTKs and their roles in invertebrates and in humans, as well as downstream signaling pathways. The assembly of chapters is written by experts and underscores commonalities between and among the RTKs. It is an ideal companion volume to The Receptor Tyrosine Kinase: Families and Subfamilies, which proceeds, family by family through all of the specific subfamilies of RTKs, along with their unique landmarks.
Author : Doriano Fabbro
Release : 2007-11-13
Genre : Science
Kind : eBook
Book Rating : 621/5 ( reviews)
Book Synopsis Protein Tyrosine Kinases by : Doriano Fabbro
Download or read book Protein Tyrosine Kinases written by Doriano Fabbro. This book was released on 2007-11-13. Available in PDF, EPUB and Kindle. Book excerpt: Leading researchers, from the Novartis group that pioneered Gleevec/GlivecTM and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing protein kinase inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining "on-target" vs "off-target" effects of kinase inhibitors.
