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Non-Invasive Monitoring of Transdermal Drug Delivery

2022-03-23 Medical
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Release : 2022-03-23
Genre : Medical
Kind : eBook
Book Rating : 850/5 ( reviews)

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Book Synopsis Non-Invasive Monitoring of Transdermal Drug Delivery by : Pasquale Arpaia

Download or read book Non-Invasive Monitoring of Transdermal Drug Delivery written by Pasquale Arpaia. This book was released on 2022-03-23. Available in PDF, EPUB and Kindle. Book excerpt: The book presents an innovative technology based on injection of a very weak current to trace the quantity of a drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.

Transdermal Drug Delivery Systems

2019-08-30
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Release : 2019-08-30
Genre :
Kind : eBook
Book Rating : 704/5 ( reviews)

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Book Synopsis Transdermal Drug Delivery Systems by : Jonathan Hadgraft

Download or read book Transdermal Drug Delivery Systems written by Jonathan Hadgraft. This book was released on 2019-08-30. Available in PDF, EPUB and Kindle. Book excerpt: Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulatory approval.

Handbook of Non-Invasive Drug Delivery Systems

2009-12-31 Science
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Release : 2009-12-31
Genre : Science
Kind : eBook
Book Rating : 263/5 ( reviews)

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Book Synopsis Handbook of Non-Invasive Drug Delivery Systems by : Vitthal S. Kulkarni

Download or read book Handbook of Non-Invasive Drug Delivery Systems written by Vitthal S. Kulkarni. This book was released on 2009-12-31. Available in PDF, EPUB and Kindle. Book excerpt: With the improvements in formulation science and certain transdermal delivery technologies, the non-invasive mode of drug delivery is now ready to compete with traditional methods of oral and injectible routes of drug delivery. The Handbook of Non-Invasive Drug Delivery Systems encompasses the broad field of non-invasive drug delivery systems that include drug delivery via topical, transdermal-passive, transdermal-active (device- aided enhanced penetration), trans-mucosal membrane, trans-ocular membrane as well as delivery via alveolar membrane from inhaled medication. Patient compliance has been found to be much higher when administrated by non-invasive routes and therefore they are considered to be a preferred mode of drug delivery. The book includes both science and technological aspects of new drug delivery systems. Its unique focus is that it is on new drug delivery systems that are considered to be "non-invasive". Other unique features include a chapter on Regulatory Aspects of non-invasive systems and one on FDA guidance for topical nano-drug delivery. Two chapters covering market trends and perspectives, as well as providing guidance to those marketing such systems are also included.

Non-Invasive Monitoring of Transdermal Drug Delivery

2022-03-23 Medical
Download Non-Invasive Monitoring of Transdermal Drug Delivery PDF Online Free

Author :
Release : 2022-03-23
Genre : Medical
Kind : eBook
Book Rating : 842/5 ( reviews)

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Book Synopsis Non-Invasive Monitoring of Transdermal Drug Delivery by : Pasquale Arpaia

Download or read book Non-Invasive Monitoring of Transdermal Drug Delivery written by Pasquale Arpaia. This book was released on 2022-03-23. Available in PDF, EPUB and Kindle. Book excerpt: The book presents an innovative technology based on injection of a very weak current to trace the quantity of a drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.

Drug Delivery Applications of Noninvasive Imaging

2013-10-14 Medical
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Release : 2013-10-14
Genre : Medical
Kind : eBook
Book Rating : 837/5 ( reviews)

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Book Synopsis Drug Delivery Applications of Noninvasive Imaging by : Chun Li

Download or read book Drug Delivery Applications of Noninvasive Imaging written by Chun Li. This book was released on 2013-10-14. Available in PDF, EPUB and Kindle. Book excerpt: Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications. Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers: In vivo imaging techniques and quantitative analysis Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery Translational research leading to clinical applications Imaging drug delivery in large animal models Clinical applications of imaging techniques to guide drug development and drug delivery Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems. Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.

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