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New Cytokines as Potential Drugs

2012-11-19 Medical
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Release : 2012-11-19
Genre : Medical
Kind : eBook
Book Rating : 567/5 ( reviews)

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Book Synopsis New Cytokines as Potential Drugs by : Satwant K. Narula

Download or read book New Cytokines as Potential Drugs written by Satwant K. Narula. This book was released on 2012-11-19. Available in PDF, EPUB and Kindle. Book excerpt: Over the past ten years, a number of cytokines and growth factors have proven to be as effective therapeutics. While these products have certainly established recombinant biologics as a major pharmaceutical growth sector, the continued interest in this class of drugs arises from the fact that today we have a far better understanding of the human immune response, both at a cellular and molecular level. This has resulted in a more methodical characterisation of these factors which has given clinical researchers an opportunity to plan Phase 1 clinical trials that can provide substantial information on the activity of the cytokine in humans. Currently, a great deal of effort is also being channelled into identifying cytokines from the various DNA databases. Our major objective for this book is to profile cytokines that have been recently identified. The therapeutic potential of these cytokines based on their known properties will be discussed by the authors. The main aim of this book is to provide...

New Cytokines as Potential Drugs

2000-01 Cytokines
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Release : 2000-01
Genre : Cytokines
Kind : eBook
Book Rating : 830/5 ( reviews)

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Book Synopsis New Cytokines as Potential Drugs by : Satwant K. Narula

Download or read book New Cytokines as Potential Drugs written by Satwant K. Narula. This book was released on 2000-01. Available in PDF, EPUB and Kindle. Book excerpt:

Cytokines and Pain

2013-03-08 Medical
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Release : 2013-03-08
Genre : Medical
Kind : eBook
Book Rating : 493/5 ( reviews)

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Book Synopsis Cytokines and Pain by : L.R. Watkins

Download or read book Cytokines and Pain written by L.R. Watkins. This book was released on 2013-03-08. Available in PDF, EPUB and Kindle. Book excerpt: Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.

Cytokine Inhibitors

2000-11-14 Medical
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Release : 2000-11-14
Genre : Medical
Kind : eBook
Book Rating : 244/5 ( reviews)

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Book Synopsis Cytokine Inhibitors by : Gennaro Ciliberto

Download or read book Cytokine Inhibitors written by Gennaro Ciliberto. This book was released on 2000-11-14. Available in PDF, EPUB and Kindle. Book excerpt: Compiling an up-to-date and detailed survey of the role cytokines play in cell-to-cell communication, development, and differentiation, this comprehensive reference highlights the medical advantages of cytokine inhibition and pursues novel methods of discovery for more potent and specific blocking agents. Investigates the pathogenic role of

Innovative Medicine

2015-10-13 Science
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Release : 2015-10-13
Genre : Science
Kind : eBook
Book Rating : 516/5 ( reviews)

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Book Synopsis Innovative Medicine by : Kazuwa Nakao

Download or read book Innovative Medicine written by Kazuwa Nakao. This book was released on 2015-10-13. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

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