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Molecular Nanomachines of the Presynaptic Terminal

2016-10-18 Neurosciences. Biological psychiatry. Neuropsychiatry
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Release : 2016-10-18
Genre : Neurosciences. Biological psychiatry. Neuropsychiatry
Kind : eBook
Book Rating : 983/5 ( reviews)

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Book Synopsis Molecular Nanomachines of the Presynaptic Terminal by : Silvio O. Rizzoli

Download or read book Molecular Nanomachines of the Presynaptic Terminal written by Silvio O. Rizzoli. This book was released on 2016-10-18. Available in PDF, EPUB and Kindle. Book excerpt: Synaptic transmission is the basis of neuronal communication and is thus the most important element in brain functions, ranging from sensory input to information processing. Changes in synaptic transmission can result in the formation or dissolution of memories, and can equally lead to neurological and psychiatric disorders. The proteins composing the synapse, and their respective functions, are getting increasingly known. One aspect that has become evident in the last years is that most synaptic functions are performed not by single proteins, but by highly organized multi-protein machineries, which interact dynamically to provide responses optimally suited to the needs of the neuronal network. To decipher synaptic and neuronal function, it is essential to understand the organisational, morphological and functional aspects of the molecular nanomachines that operate at the synapse. We discuss these aspects in 11 different chapters, focusing on the structure and function of the active zone, on the functional anatomy of the synaptic vesicle, and on some of the best known soluble protein complexes from the synapse, including those involved in endocytosis and vesicle recycling.

Molecular Nanomachines of the Presynaptic Terminal, Volume II

2022-06-30 Science
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Release : 2022-06-30
Genre : Science
Kind : eBook
Book Rating : 672/5 ( reviews)

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Book Synopsis Molecular Nanomachines of the Presynaptic Terminal, Volume II by : Silvio O. Rizzoli

Download or read book Molecular Nanomachines of the Presynaptic Terminal, Volume II written by Silvio O. Rizzoli. This book was released on 2022-06-30. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Nanomachines of the Presynaptic Terminal

2016
Download Molecular Nanomachines of the Presynaptic Terminal PDF Online Free

Author :
Release : 2016
Genre :
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Molecular Nanomachines of the Presynaptic Terminal by :

Download or read book Molecular Nanomachines of the Presynaptic Terminal written by . This book was released on 2016. Available in PDF, EPUB and Kindle. Book excerpt: Synaptic transmission is the basis of neuronal communication and is thus the most important element in brain functions, ranging from sensory input to information processing. Changes in synaptic transmission can result in the formation or dissolution of memories, and can equally lead to neurological and psychiatric disorders. The proteins composing the synapse, and their respective functions, are getting increasingly known. One aspect that has become evident in the last years is that most synaptic functions are performed not by single proteins, but by highly organized multi-protein machineries, which interact dynamically to provide responses optimally suited to the needs of the neuronal network. To decipher synaptic and neuronal function, it is essential to understand the organisational, morphological and functional aspects of the molecular nanomachines that operate at the synapse. We discuss these aspects in 11 different chapters, focusing on the structure and function of the active zone, on the functional anatomy of the synaptic vesicle, and on some of the best known soluble protein complexes from the synapse, including those involved in endocytosis and vesicle recycling.

Presynaptic Terminals

2015-01-23 Medical
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Release : 2015-01-23
Genre : Medical
Kind : eBook
Book Rating : 662/5 ( reviews)

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Book Synopsis Presynaptic Terminals by : Sumiko Mochida

Download or read book Presynaptic Terminals written by Sumiko Mochida. This book was released on 2015-01-23. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together leading international experts to discuss recent advances in functional studies on key proteins and protein complexes involved in each synaptic vesicle phase. These include proteins that control the final step of neurotransmitter release, in response to a neural signal, and the first step of vesicle endocytosis, which helps maintain stable neurotransmitter release in response to unceasing neural signals arriving at presynaptic terminals. Neural networks transmit input and output signals of action potentials using chemical synapses. The strength of the signal from one to another neuron can be tuned by the neural signal itself as it induces Ca2+ entry and by other neurons’ signals that modify Ca2+ entry through voltage-gated Ca2+ channels at the active zone, where chemical neurotransmitters are released from synaptic vesicles via exocytosis. Synaptic vesicles are docked and primed at the active zone prior to exocytosis and are endocytosed after exocytosis for reuse at a small presynaptic terminal. Recycled vesicles are refilled with transmitters and stored for a future round of exocytosis. Thus, synaptic vesicles in presynaptic terminals go through various phases. Each vesicle phase is well orchestrated by numerous proteins and advance step-by-step with neural activities. The fine regulations of synaptic vesicle phases by numerous proteins is an exciting subject, and systematic, well-organized explanations in this book will help the reader easily learn about complicated molecular mechanisms in presynaptic terminals.

The Road from Nanomedicine to Precision Medicine

2020-01-06 Medical
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Release : 2020-01-06
Genre : Medical
Kind : eBook
Book Rating : 401/5 ( reviews)

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Book Synopsis The Road from Nanomedicine to Precision Medicine by : Shaker. A Mousa

Download or read book The Road from Nanomedicine to Precision Medicine written by Shaker. A Mousa. This book was released on 2020-01-06. Available in PDF, EPUB and Kindle. Book excerpt: The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.

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