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Molecular And Cellular Aspects Of The Serpinopathies And Disorders In Serpin Activity

2007-02-27 Medical
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Release : 2007-02-27
Genre : Medical
Kind : eBook
Book Rating : 214/5 ( reviews)

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Book Synopsis Molecular And Cellular Aspects Of The Serpinopathies And Disorders In Serpin Activity by : Gary A Silverman

Download or read book Molecular And Cellular Aspects Of The Serpinopathies And Disorders In Serpin Activity written by Gary A Silverman. This book was released on 2007-02-27. Available in PDF, EPUB and Kindle. Book excerpt: Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition. In humans, serpins constitute 10% of the plasma proteins and are best known as critical regulators of both the thrombotic and fibrinolytic systems. Serpins also participate in the regulation of the complement cascade, angiogenesis, tumor metastasis, apoptosis and innate immunity. Considering the importance of these molecules in regulating proteolytic cascades, it is not surprising to find that loss- and gain-of-function mutations result in significant human diseases.Massive thrombosis or bleeding, hereditary angioedema, Alzheimer's disease, diabetic angiopathy and tumor invasion are some of the human diseases associated with serpins. In addition, mutations that alter serpin conformations (the serpinopathies) lead to lung disease, cirrhosis and a form of familial dementia. The goal of this text is to present the current knowledge on the molecular and cellular basis of serpins and their diseases.

Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity

2007 Medical
Download Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity PDF Online Free

Author :
Release : 2007
Genre : Medical
Kind : eBook
Book Rating : 634/5 ( reviews)

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Book Synopsis Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity by : Gary A. Silverman

Download or read book Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity written by Gary A. Silverman. This book was released on 2007. Available in PDF, EPUB and Kindle. Book excerpt: Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition. In humans, serpins constitute 10% of the plasma proteins and are best known as critical regulators of both the thrombotic and fibrinolytic systems. Serpins also participate in the regulation of the complement cascade, angiogenesis, tumor metastasis, apoptosis and innate immunity. Considering the importance of these molecules in regulating proteolytic cascades, it is not surprising to find that loss- and gain-of-function mutations result in significant human diseases.Massive thrombosis or bleeding, hereditary angioedema, Alzheimer's disease, diabetic angiopathy and tumor invasion are some of the human diseases associated with serpins. In addition, mutations that alter serpin conformations (the serpinopathies) lead to lung disease, cirrhosis and a form of familial dementia. The goal of this text is to present the current knowledge on the molecular and cellular basis of serpins and their diseases.

Extracellular Targeting of Cell Signaling in Cancer

2018-05-10 Science
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Release : 2018-05-10
Genre : Science
Kind : eBook
Book Rating : 207/5 ( reviews)

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Book Synopsis Extracellular Targeting of Cell Signaling in Cancer by : James W. Janetka

Download or read book Extracellular Targeting of Cell Signaling in Cancer written by James W. Janetka. This book was released on 2018-05-10. Available in PDF, EPUB and Kindle. Book excerpt: International experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than non-selective, toxic chemotherapy. With contributions from an international panel of experts in the field, the book integrates diverse aspects of biochemistry, molecular biology, protein engineering, proteomics, cell biology, pharmacology, biophysics, structural biology, medicinal chemistry and drug development. A large class of proteins called kinases are enzymes required by cancer cells to grow, proliferate, and survive apoptosis (death) by the immune system. Two important kinases are MET and RON which are receptor tyrosine kinases (RTKs) that initiate cell signaling pathways outside the cell surface in response to extracellular ligands (growth factors.) Both kinases are oncogenes which are required by cancer cells to migrate away from the primary tumor, invade surrounding tissue and metastasize. MET and RON reside on both cancer cells and the support cells surrounding the tumor, called the microenvironment. MET and RON are activated by their particular ligands, the growth factors HGF and MSP, respectively. Blocking MET and RON kinase activation and downstream signaling is a promising therapeutic strategy for preventing tumor progression and metastasis. Written for cancer physicians and biologists as well as drug discovery and development teams in both industry and academia, this is the first book of its kind which explores novel approaches to inhibit MET and RON kinases other than traditional small molecule kinase inhibitors. These new strategies target key tumorigenic processes on the outside of the cell, such as growth factor activation by proteases. These unique strategies have promising potential as an improved alternative to kinase inhibitors, chemotherapy, or radiation treatment.

The Serpin Family

2015-11-13 Science
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Release : 2015-11-13
Genre : Science
Kind : eBook
Book Rating : 114/5 ( reviews)

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Book Synopsis The Serpin Family by : Margarethe Geiger

Download or read book The Serpin Family written by Margarethe Geiger. This book was released on 2015-11-13. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an comprehensive overview on biology, genetics and cellular functions of serpins (serine protease inhibitors) in health and disease. With over 1000 members serpins are the most diverse family of protease inhibitors. Latest groundbreaking research findings are presented and broaden the understanding on inhibitory and non-inhibitory serpins, not only in mammalian organisms but also in insects, worms, plants and viruses.​

Proteases and Their Receptors in Inflammation

2011-08-03 Medical
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Release : 2011-08-03
Genre : Medical
Kind : eBook
Book Rating : 572/5 ( reviews)

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Book Synopsis Proteases and Their Receptors in Inflammation by : Nathalie Vergnolle

Download or read book Proteases and Their Receptors in Inflammation written by Nathalie Vergnolle. This book was released on 2011-08-03. Available in PDF, EPUB and Kindle. Book excerpt: Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest. In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response. This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.).

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