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Microarray Innovations

2009-04-02 Medical
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Release : 2009-04-02
Genre : Medical
Kind : eBook
Book Rating : 513/5 ( reviews)

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Book Synopsis Microarray Innovations by : Gary Hardiman

Download or read book Microarray Innovations written by Gary Hardiman. This book was released on 2009-04-02. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarr

Microarray Technology and Its Applications

2006-03-30 Medical
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Release : 2006-03-30
Genre : Medical
Kind : eBook
Book Rating : 783/5 ( reviews)

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Book Synopsis Microarray Technology and Its Applications by : Uwe R. Müller

Download or read book Microarray Technology and Its Applications written by Uwe R. Müller. This book was released on 2006-03-30. Available in PDF, EPUB and Kindle. Book excerpt: Ithasbeenstatedthatourknowledgedoublesevery20years,butthatmaybe an understatement when considering the Life Sciences. A series of discoveries and inventions have propelled our knowledge from the recognition that DNA isthegeneticmaterialtoabasicmolecularunderstandingofourselvesandthe living world around us in less than 50 years. Crucial to this rapid progress was thediscoveryofthedouble-helicalstructureofDNA,whichlaidthefoundation forallhybridizationbasedtechnologies. Thediscoveriesofrestrictionenzymes, ligases, polymerases, combined with key innovations in DNA synthesis and sequencing ushered in the era of biotechnologyas a new science with profound sociological and economic implications that are likely to have a dominating in?uence on the development of our society during this century. Given the process by which science builds on prior knowledge, it is perhaps unfair to single out a few inventions and credit them with having contributed most to thisavalancheofknowledge. Yet,therearesurelysomethatwillberecognized as having had a more profound impact than others, not just in the furthering of our scienti?c knowledge, but by leveraging commercial applications that provide a tangible return to our society. The now famous Polymerase Chain Reaction, or PCR, is surely one of those, as it has uniquely catalyzed molecular biology during the past 20 years, and continues to have a signi?cant impact on all areas that involve nucleic acids, ranging from molecular pathology to forensics. Ten years ago micro- ray technology emerged as a new and powerful tool to study nucleic acid - quences in a highly multiplexed manner, and has since found equally exciting and useful applications in the study of proteins, metabolites, toxins, viruses, whole cells and even tissues.

Microarray Biochip Technology

2000 Medical
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Release : 2000
Genre : Medical
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Microarray Biochip Technology by : Mark Schena

Download or read book Microarray Biochip Technology written by Mark Schena. This book was released on 2000. Available in PDF, EPUB and Kindle. Book excerpt: Technology standards for microarray research (M. Schena, R. W. Davis). Microfluidic technologies and instrumentation for printing DNA microarrays (Don Rose). Novel microarray printing and detection technologies (M. L. Mace Júnior, J. Montagu, Stanley D. Rose, G. McGuinness). A systems approach to fabricating and analyzing DNA microarrayss (J. Worley, K. Bechtol, S. Penn, D. Roach, D. hanzel, M. Trounstine, D. B.). The flow-thru chip: a three-dimensional biochip platform (A. Stell, M. Torres, J. Hartwell, Yong-Yi Yu, Nan Ting, G. Hoke, H. Yang). Large-scale genomic analysis using affymetrix genechip probe arrays (J. A. Warrington, S. Dee, M. Trulson). Technology and applications of gene expression microarrays (E. Evertsz, P. Starink, R. Gupta, D. Watson). Information processing issues and solutions associated with microarray technology (Y.-X. Zhou, P. Kalocsai, J.-Y. Chen, S. Shams). Microarray tools, kits, reagents, and services (T. Martinsky, P. Haje). Micromax: a highly sensitive system for differential gene expression on microarrays (K. Adler, J. Broadbent, R. Garlick, R. Joseph, A. Khimani, A. Mikulskis, P. Rapiejko, J. Killian). Production of microarrays on porous substrates using noncontact piezoelectric dispensing (D. Englert). Arrayed primer extension on the DNA chip: method and applications (N. Tonisson, A. Kurg, E. Lõhmussaar, A. Metspalu). Overview of a microarray scanner: design essentials for an integrated acquisition and analysis platform (T. Basarsky, D. Verdnik, J. Ye Zhai, D. Wellis). Selected supplier list. Index.

Microarrays

2014 Science
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Release : 2014
Genre : Science
Kind : eBook
Book Rating : 492/5 ( reviews)

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Book Synopsis Microarrays by : Zhili He

Download or read book Microarrays written by Zhili He. This book was released on 2014. Available in PDF, EPUB and Kindle. Book excerpt: Microorganisms are the most diverse group of organisms and play important and distinctive roles in their ecosystems. They interact with their peers and other organisms (e.g., plants, animals) to form a complicated food web, significantly impacting ecosystem functions and services. However, understanding the diversity, composition, structure, function, activity, and dynamics of microbial communities remains challenging. Over the past decade, microarray-based technologies have been developed to address such challenges. This book is focused on current microarray technologies and their applications in environmental microbiology. In the first chapter, microarray technologies and applications are briefly introduced and, in following chapters, microarray probe design, development and evaluation, and data analysis are described in detail. In later chapters, more attention is paid to phylogenetic arrays (e.g., PhyloChip) and functional gene arrays (e.g., GeoChip). These generic tools - for analyzing microbial communities from disparate environments, ecosystems, and habitats (including soil, water, sediment, animals, and humans) - are described in detail with examples of specific applications. Also included are microarrays for analyzing microbial communities from specific environments, such as soil, bioleaching ecosystems, and human microbiomes, as well as microarrays for detecting specific microorganisms (e.g., pathogens) in the environment. The book's contributors also discuss the advantages and limitations of microarray technologies compared to high throughput sequencing technologies. This book is recommended for anyone working on microbial communities, biofilms, or environmental microbiology. [Subject: Microbiology, Life Science, Environmental Science]

Methods in Microarray Normalization

2008-01-31 Mathematics
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Release : 2008-01-31
Genre : Mathematics
Kind : eBook
Book Rating : 799/5 ( reviews)

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Book Synopsis Methods in Microarray Normalization by : Phillip Stafford

Download or read book Methods in Microarray Normalization written by Phillip Stafford. This book was released on 2008-01-31. Available in PDF, EPUB and Kindle. Book excerpt: This organized text compiles, for the first time, the most useful normalization methods developed for interpreting microarray data. Experts examine the mathematical processes that are important in normalizing data and avoiding inherent systematic biases. They also review modern software, including discussions on key algorithms, comparative data, and download locations. The book contains the latest microarray innovations from companies such as Agilent, Affymetrix, and GeneGo as well as new, readily adaptable normalization methods for expression and CGH arrays. It also lists of open-source molecular profiling normalization algorithms available and where to access them.

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