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Mechanism of Functional Expression of F1-ATPase

2021-02-15 Science
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Release : 2021-02-15
Genre : Science
Kind : eBook
Book Rating : 314/5 ( reviews)

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Book Synopsis Mechanism of Functional Expression of F1-ATPase by : Masahiro Kinoshita

Download or read book Mechanism of Functional Expression of F1-ATPase written by Masahiro Kinoshita. This book was released on 2021-02-15. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a new view of the mechanism of functional expression of ATP-driven motors (proteins or protein complexes). It is substantially different from the prevailing idea that the motor converts chemical energy to mechanical work. To facilitate understanding, the differences between the new and prevailing views are explained using many illustrations. The book is of interest to those who are not convinced of the notion of chemo–mechanical coupling. The claims presented are the following: The system, which comprises not only the motor but also water, does no mechanical work during the ATP hydrolysis cycle; a protein is moved or a protein in the complex is rotated by the entropic force generated by water. The highlight of the explanation in the book is that the mechanism of unidirectional rotation of the central shaft in F1-ATPase is discussed in detail on the basis of this new view. The hydration entropy of each β subunit to which a specific chemical compound (ATP, ADP and Pi, Pi, or nothing) is bound, the hydration entropy of the α3β3 complex, and the dependence of the hydration entropy of F1-ATPase on the orientation of the γ subunit play essential roles.

Mechanism of Functional Expression of F1-ATPase

2020-12-30 Science
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Release : 2020-12-30
Genre : Science
Kind : eBook
Book Rating : 324/5 ( reviews)

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Book Synopsis Mechanism of Functional Expression of F1-ATPase by : Masahiro Kinoshita

Download or read book Mechanism of Functional Expression of F1-ATPase written by Masahiro Kinoshita. This book was released on 2020-12-30. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a new view of the mechanism of functional expression of ATP-driven motors (proteins or protein complexes). It is substantially different from the prevailing idea that the motor converts chemical energy to mechanical work. To facilitate understanding, the differences between the new and prevailing views are explained using many illustrations. The book is of interest to those who are not convinced of the notion of chemo–mechanical coupling. The claims presented are the following: The system, which comprises not only the motor but also water, does no mechanical work during the ATP hydrolysis cycle; a protein is moved or a protein in the complex is rotated by the entropic force generated by water. The highlight of the explanation in the book is that the mechanism of unidirectional rotation of the central shaft in F1-ATPase is discussed in detail on the basis of this new view. The hydration entropy of each β subunit to which a specific chemical compound (ATP, ADP and Pi, Pi, or nothing) is bound, the hydration entropy of the α3β3 complex, and the dependence of the hydration entropy of F1-ATPase on the orientation of the γ subunit play essential roles.

Mechanism of Functional Expression of F1-ATPase: A New View on Mechanism of Functional Expression of an ATP-Driven Motor

2021
Download Mechanism of Functional Expression of F1-ATPase: A New View on Mechanism of Functional Expression of an ATP-Driven Motor PDF Online Free

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Release : 2021
Genre :
Kind : eBook
Book Rating : 338/5 ( reviews)

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Book Synopsis Mechanism of Functional Expression of F1-ATPase: A New View on Mechanism of Functional Expression of an ATP-Driven Motor by : Masahiro Kinoshita

Download or read book Mechanism of Functional Expression of F1-ATPase: A New View on Mechanism of Functional Expression of an ATP-Driven Motor written by Masahiro Kinoshita. This book was released on 2021. Available in PDF, EPUB and Kindle. Book excerpt:

Mechanism of Functional Expression of the Molecular Machines

2016-06-14 Science
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Release : 2016-06-14
Genre : Science
Kind : eBook
Book Rating : 868/5 ( reviews)

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Book Synopsis Mechanism of Functional Expression of the Molecular Machines by : Masahiro Kinoshita

Download or read book Mechanism of Functional Expression of the Molecular Machines written by Masahiro Kinoshita. This book was released on 2016-06-14. Available in PDF, EPUB and Kindle. Book excerpt: This brief discusses the mechanism of functional expression of a protein or protein complex utilizing the ATP hydrolysis cycle or proton-motive force from a unique point of view focused on the roles of water. A variety of processes are considered such as the unidirectional movement of a linear-motor protein along a filament, insertion of an unfolded protein into a chaperonin and release of the folded protein from it, transport of diverse substrates across the membrane by a transporter, and directed rotation of the central subunit within a rotatory motor protein complex. These topics are discussed in a unified manner within the same theoretical framework. The author argues that water plays imperative roles in the functional expression of these molecular machines. A pivotal factor is the entropic force or potential originating from the translational displacement of water molecules coexisting with the molecular machines in the entire system.

Biochemical Thermodynamics

2006-03-31 Science
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Release : 2006-03-31
Genre : Science
Kind : eBook
Book Rating : 451/5 ( reviews)

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Book Synopsis Biochemical Thermodynamics by : Robert A. Alberty

Download or read book Biochemical Thermodynamics written by Robert A. Alberty. This book was released on 2006-03-31. Available in PDF, EPUB and Kindle. Book excerpt: Navigate the complexities of biochemical thermodynamics with Mathematica(r) Chemical reactions are studied under the constraints of constant temperature and constant pressure; biochemical reactions are studied under the additional constraints of pH and, perhaps, pMg or free concentrations of other metal ions. As more intensive variables are specified, more thermodynamic properties of a system are defined, and the equations that represent thermodynamic properties as a function of independent variables become more complicated. This sequel to Robert Alberty's popular Thermodynamics of Biochemical Reactions describes how researchers will find Mathematica(r) a simple and elegant tool, which makes it possible to perform complex calculations that would previously have been impractical. Biochemical Thermodynamics: Applications of Mathematica(r) provides a comprehensive and rigorous treatment of biochemical thermodynamics using Mathematica(r) to practically resolve thermodynamic issues. Topics covered include: * Thermodynamics of the dissociation of weak acids * Apparent equilibrium constants * Biochemical reactions at specified temperatures and various pHs * Uses of matrices in biochemical thermodynamics * Oxidoreductase, transferase, hydrolase, and lyase reactions * Reactions at 298.15K * Thermodynamics of the binding of ligands by proteins * Calorimetry of biochemical reactions Because Mathematica(r) allows the intermingling of text and calculations, this book has been written in Mathematica(r) and includes a CD-ROM containing the entire book along with macros that help scientists and engineers solve their particular problems.

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