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Lyophilization of Biopharmaceuticals

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Release : 2005-12-05
Genre : Medical
Kind : eBook
Book Rating : 768/5 ( reviews)

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Book Synopsis Lyophilization of Biopharmaceuticals by : Henry R. Costantino

Download or read book Lyophilization of Biopharmaceuticals written by Henry R. Costantino. This book was released on 2005-12-05. Available in PDF, EPUB and Kindle. Book excerpt: Humans have been experimenting with lyophilization, or freeze-drying, as a method to preserve biological structures for over a thousand years. This comprehensive volume, intended for scientists in both academia and industry, covers a wide range of topics relevant to the formulation of peptide and protein drugs in the freeze-dried state.

Lyophilization of Pharmaceuticals and Biologicals

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Release : 2018-12-13
Genre : Medical
Kind : eBook
Book Rating : 270/5 ( reviews)

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Book Synopsis Lyophilization of Pharmaceuticals and Biologicals by : Kevin R. Ward

Download or read book Lyophilization of Pharmaceuticals and Biologicals written by Kevin R. Ward. This book was released on 2018-12-13. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume brings together leading practitioners in the freeze-drying community to address recent progress, not only in new analytical tools and applications of the data derived in cycle design but also in the manufacturing of lyophilized products in the healthcare sector – whether these be therapeutics, vaccines or diagnostic products - and indeed the equipment to deliver this scale of freeze-drying. Areas of focus include analytical and formulation issues, process monitoring and control, as well as post-lyophilization analysis. Written for the Methods in Pharmacology and Toxicology series, chapters include the type of expert advice that leads to superior results in the lab. Authoritative and practical, Lyophilization of Pharmaceuticals and Biologicals: New Technologies and Approaches serves as an ideal guide for researchers working in or just seeking an update on this rapidly changing field.

Lyophilization

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Release : 1999-08-31
Genre : Medical
Kind : eBook
Book Rating : 810/5 ( reviews)

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Book Synopsis Lyophilization by : Thomas A. Jennings

Download or read book Lyophilization written by Thomas A. Jennings. This book was released on 1999-08-31. Available in PDF, EPUB and Kindle. Book excerpt: Finding consistent, analytical discussions of processes and principles of lyophilization can be challenging and often frustrating. The first resource to gather information about the field, Lyophilization: Introduction and Basic Principles is still the book to have on lyophilization. Presenting information in an easy-to-read style, the book comprehensively and authoritatively covers the field. Using plain, unpretentious language, author Thomas A. Jennings pulls together information from diverse sources to provide an authoritative compendium of the lyophilization process and its basic principles. He provides important discussions about the nature of the container-closure system and the equipment, tools, and environments required. Case studies and examples of solutions illustrate the many ways problems can be addressed in the lyophilization process. The book covers: Properties of lyophilized materials Product formulation requirements and the thermal properties of formulations Importance of process water Phase changes Thermal analytical methods Freezing, primary, and secondary drying processes Effect of vacuum freeze-dryers, both now and in the future Including over 150 illustrations, global symbols, and more than 350 references, this book is the complete guide to lyophilization, its analytical methods, measurement of process parameters, and equipment.

Principles and Practices of Lyophilization in Product Development and Manufacturing

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Release : 2023-04-24
Genre : Medical
Kind : eBook
Book Rating : 343/5 ( reviews)

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Book Synopsis Principles and Practices of Lyophilization in Product Development and Manufacturing by : Feroz Jameel

Download or read book Principles and Practices of Lyophilization in Product Development and Manufacturing written by Feroz Jameel. This book was released on 2023-04-24. Available in PDF, EPUB and Kindle. Book excerpt: The biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T cell engager ( BITES), Dual Variable Domain ( DVD), Chimeric Antigen Receptor - Modified Tcells (CART) that are currently being used as therapeutic agents for immunology and oncology disease conditions. In addition to other pharmaceuticals and biopharmaceuticals, all these novel formats are fragile with respect to their stability/structure under processing conditions meaning marginal stability in the liquid state and often require lyophilization to enhance their stability and shelf-life. This book contains chapters/topics that will describe every aspect of the lyophilization process and product development and manufacturing starting from the overview of lyophilization process, equipment required, characterization of the material, design and development of the formulation and lyophilization process, various techniques for characterization of the product, scale-up/tech-transfer and validation. It also describes the application of CFD coupled with mathematical modeling in the lyophilization process and product development, scale-up, and manufacturing. Additionally, Principles and Practice of Lyophilization Process and Product Development contains an entire dedicated section on “Preservation of Biologicals” comprised of nine chapters written by experts and including case studies.

Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products

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Release : 2016-04-19
Genre : Medical
Kind : eBook
Book Rating : 769/5 ( reviews)

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Book Synopsis Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products by : Louis Rey

Download or read book Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products written by Louis Rey. This book was released on 2016-04-19. Available in PDF, EPUB and Kindle. Book excerpt: Freeze-drying, or lyophilization, is a well established technology used in the preservation of numerous pharmaceutical and biological products. This highly effective dehydration method involves the removal of water from frozen materials via the direct sublimation of ice. In recent years, this process has met with many changes, as have the regulatio

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