Longevity, Senescence, and the Genome

1994-05-16 Health & Fitness

Author : Caleb E. Finch
Release : 1994-05-16
Genre : Health & Fitness
Kind : eBook
Book Rating : 899/5 ( reviews)

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Book Synopsis Longevity, Senescence, and the Genome by : Caleb E. Finch

Download or read book Longevity, Senescence, and the Genome written by Caleb E. Finch. This book was released on 1994-05-16. Available in PDF, EPUB and Kindle. Book excerpt: Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging. To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral, developmental, evolutionary, and molecular biology. By comparing species that have different developmental and life spans, Finch proposes an original typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants.

Longevity Genes

2015-04-27 Medical

Author : Gil Atzmon, PhD
Release : 2015-04-27
Genre : Medical
Kind : eBook
Book Rating : 044/5 ( reviews)

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Book Synopsis Longevity Genes by : Gil Atzmon, PhD

Download or read book Longevity Genes written by Gil Atzmon, PhD. This book was released on 2015-04-27. Available in PDF, EPUB and Kindle. Book excerpt: The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.

Biology of Longevity and Aging

2019-01-10 Family & Relationships

Author : Robert Arking
Release : 2019-01-10
Genre : Family & Relationships
Kind : eBook
Book Rating : 966/5 ( reviews)

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Book Synopsis Biology of Longevity and Aging by : Robert Arking

Download or read book Biology of Longevity and Aging written by Robert Arking. This book was released on 2019-01-10. Available in PDF, EPUB and Kindle. Book excerpt: An introductory text to the biology of aging and longevity, offering a thorough review of the field.

How We Age

2023-11-14 Science

Author : Coleen T. Murphy
Release : 2023-11-14
Genre : Science
Kind : eBook
Book Rating : 332/5 ( reviews)

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Book Synopsis How We Age by : Coleen T. Murphy

Download or read book How We Age written by Coleen T. Murphy. This book was released on 2023-11-14. Available in PDF, EPUB and Kindle. Book excerpt: How recent breakthroughs in longevity research offer clues about human aging All of us would like to live longer, or to slow the debilitating effects of age. In How We Age, Coleen Murphy shows how recent research on longevity and aging may be bringing us closer to this goal. Murphy, a leading scholar of aging, explains that the study of model systems, particularly simple invertebrate animals, combined with breakthroughs in genomic methods, have allowed scientists to probe the molecular mechanisms of longevity and aging. Understanding the fundamental biological rules that govern aging in model systems provides clues about how we might slow human aging, which could lead in turn to new therapeutics and treatments for age-related disease. Among other vivid examples, Murphy describes research that shows how changing a single gene in the nematode worm C. elegans doubles its lifespan, extending not only the end of life but also the youthful, healthy part of life. Drawing on work in her own lab as well as other recent research, Murphy chronicles the history and current state of the field, explaining longevity’s links to reproduction and mating, sensory and cognitive function, inheritances from our ancestors, and the gut microbiome. Written with clarity and wit, How We Age provides a guide to the science: what we know about aging, how we know what we know, and what we can do with this new knowledge.

The Biology of Human Longevity

2010-07-28 Medical

Author : Caleb E. Finch
Release : 2010-07-28
Genre : Medical
Kind : eBook
Book Rating : 947/5 ( reviews)

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Book Synopsis The Biology of Human Longevity by : Caleb E. Finch

Download or read book The Biology of Human Longevity written by Caleb E. Finch. This book was released on 2010-07-28. Available in PDF, EPUB and Kindle. Book excerpt: Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists Provides a novel synthesis of existing ideas about the biology of longevity and aging Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

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Longevity, Senescence, and the Genome

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How We Age

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