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Ion channel screening: advances in technologies and analysis

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Book Synopsis Ion channel screening: advances in technologies and analysis by : Ralf F. Kettenhofen

Download or read book Ion channel screening: advances in technologies and analysis written by Ralf F. Kettenhofen. This book was released on . Available in PDF, EPUB and Kindle. Book excerpt: Ion channel research has increased tremendously in the past 35 years since the first publication of the patch clamp technique by Neher and Sakmann in 1976. This is documented by the rising number of publications listed in Pubmed (http://www.ncbi.nlm.nih.gov/pubmed) including the keyword ‘ion channel’ from just 186 hits in 1976 to almost 180,000 hits today. Ion channels attract this great interest due to their pivotal role in the control of fundamental physiological processes in a plethora of different tissues. Moreover, their importance in a wide range of inherited and drug-induced pathologies spanning all major therapeutic areas makes them attractive targets for pharmacological drug screening and potential risk factors when assessing drug safety (Ashcroft, 2006; Clare, 2010; Dunlop 2008; Milligan 2009). Several methods and technologies have been developed to meet the analytical needs for studying ion channels. These approaches have addressed ion channel function directly as well as in the context of the cell and tissue. Scaling of these technologies has allowed ion channel analysis to be carried out on high throughput and high content assay systems. In this Research Topic we want to provide an up-to-date collection of the latest developments and improvements in ion channel screening; defining the cutting edge and indicating further developments required in the future.

Expression and Analysis of Recombinant Ion Channels

2006-08-21 Science
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Release : 2006-08-21
Genre : Science
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Book Rating : 935/5 ( reviews)

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Book Synopsis Expression and Analysis of Recombinant Ion Channels by : Jeffrey J. Clare

Download or read book Expression and Analysis of Recombinant Ion Channels written by Jeffrey J. Clare. This book was released on 2006-08-21. Available in PDF, EPUB and Kindle. Book excerpt: Filling the gap created over the past five years, during which many new techniques have entered the market, this book is directed at both the new and the experienced ion channel researcher wishing to learn more about the considerations and methods for studying recombinant ion channels. These latest developments are covered here for the first time, contributed by editors and authors working for major pharmaceutical companies and who routinely apply these techniques in their daily work. The first three chapters cover the use of the Xenopus oocyte expression system for structure-function studies, from basic approaches for manipulating ion channel cDNAs to more specialized but powerful techniques. This is followed by reviews of strategies and methodologies available for expressing channels in mammalian cells and for their analysis by patch-clamp electrophysiology. Chapters 6 to 8 review the latest methodologies for ion channel drug discovery, including high throughput screening using fluorescence and luminescence, as well as automated planar array electrophysiology. The remaining two chapters focus on approaches for determining ion channel crystal structures and on computational approaches to understanding channel mechanisms at atomic resolution. Rather than provide detailed protocols, indicated by references in each chapter, the authors provide a comprehensive and easily accessible overview of the techniques involved, reviewing underlying principles and providing working guidelines as well as an understanding of the key theoretical and practical considerations associated with each topic. In each case, this practical advice is illustrated by real life examples, taken either from the author's own experience or from key examples in the literature, providing valuable practical hints not found elsewhere. The result is a compendium of practical ion channel information that will prove a valuable resource to academic and industrial workers alike.

Advances in Ion Channel Drug Discovery

2013
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Release : 2013
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Book Synopsis Advances in Ion Channel Drug Discovery by : Wilma Keighly

Download or read book Advances in Ion Channel Drug Discovery written by Wilma Keighly. This book was released on 2013. Available in PDF, EPUB and Kindle. Book excerpt: Advances in target validation, screening technologies, and discovery of new ion channel families combine to enable the investigation and commercialization of this largely unexploited target family with potential in a range of major therapeutic areas.

Ion Channel Drug Discovery

2014-09-03 Science
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Release : 2014-09-03
Genre : Science
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Book Rating : 085/5 ( reviews)

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Book Synopsis Ion Channel Drug Discovery by : Brian Cox

Download or read book Ion Channel Drug Discovery written by Brian Cox. This book was released on 2014-09-03. Available in PDF, EPUB and Kindle. Book excerpt: Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium in February 2009. This book builds on the platform created by that meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels. The editors have built an extensive network of contacts in the field through their first-hand scientific experience, collaborations and conference participation and the organisation of the meeting at Novartis, Horsham, increased the network enabling the editors to draw on the experience of eminent researchers in the field. Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new 'ion channel drug discoverer'. The book has contributions from highly respected academic researchers, industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.

Advances in Ion Channel Drug Discovery

2012
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Release : 2012
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Book Synopsis Advances in Ion Channel Drug Discovery by : Wilma Keighley

Download or read book Advances in Ion Channel Drug Discovery written by Wilma Keighley. This book was released on 2012. Available in PDF, EPUB and Kindle. Book excerpt: Advances in target validation, screening technologies, and discovery of new ion channel families combine to enable the investigation and commercialization of this largely unexploited target family with potential in a range of major therapeutic areas.

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