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Introduction to Macromolecular Binding Equilibria

2007-11-08 Science
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Release : 2007-11-08
Genre : Science
Kind : eBook
Book Rating : 993/5 ( reviews)

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Book Synopsis Introduction to Macromolecular Binding Equilibria by : Charles P. Woodbury

Download or read book Introduction to Macromolecular Binding Equilibria written by Charles P. Woodbury. This book was released on 2007-11-08. Available in PDF, EPUB and Kindle. Book excerpt: Macromolecules in the body form noncovalent associations, such as DNA-protein or protein-protein complexes, that control and regulate numerous cellular functions. Understanding how changes in the concentration and conformation of these macromolecules can trigger physiological responses is essential for researchers developing drug therapies to treat

Equilibria and Kinetics of Biological Macromolecules

2013-10-22 Science
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Release : 2013-10-22
Genre : Science
Kind : eBook
Book Rating : 770/5 ( reviews)

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Book Synopsis Equilibria and Kinetics of Biological Macromolecules by : Prof. Jan Hermans

Download or read book Equilibria and Kinetics of Biological Macromolecules written by Prof. Jan Hermans. This book was released on 2013-10-22. Available in PDF, EPUB and Kindle. Book excerpt: Progressively builds a deep understanding of macromolecular behavior Based on each of the authors' roughly forty years of biophysics research and teaching experience, this text instills readers with a deep understanding of the biophysics of macromolecules. It sets a solid foundation in the basics by beginning with core physical concepts such as thermodynamics, quantum chemical models, molecular structure and interactions, and water and the hydrophobic effect. Next, the book examines statistical mechanics, protein-ligand binding, and conformational stability. Finally, the authors address kinetics and equilibria, exploring underlying theory, protein folding, and stochastic models. With its strong emphasis on molecular interactions, Equilibria and Kinetics of Biological Macromolecules offers new insights and perspectives on proteins and other macromolecules. The text features coverage of: Basic theory, applications, and new research findings Related topics in thermodynamics, quantum mechanics, statistical mechanics, and molecular simulations Principles and applications of molecular simulations in a dedicated chapter and interspersed throughout the text Macromolecular binding equilibria from the perspective of statistical mechanics Stochastic processes related to macromolecules Suggested readings at the end of each chapter include original research papers, reviews and monographs, enabling readers to explore individual topics in greater depth. At the end of the text, ten appendices offer refreshers on mathematical treatments, including probability, computational methods, Poisson equations, and defining molecular boundaries. With its classroom-tested pedagogical approach, Equilibria and Kinetics of Biological Macromolecules is recommended as a graduate-level textbook for biophysics courses and as a reference for researchers who want to strengthen their understanding of macromolecular behavior.

Binding and Linkage

1990 Science
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Release : 1990
Genre : Science
Kind : eBook
Book Rating : 569/5 ( reviews)

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Book Synopsis Binding and Linkage by : Jeffries Wyman

Download or read book Binding and Linkage written by Jeffries Wyman. This book was released on 1990. Available in PDF, EPUB and Kindle. Book excerpt: Ligand-macromolecule interactions are of fundamental importance in the control of biological processes. This book applies the principles of linkage thermodynamics to polyfunctional macromolecular systems under equilibrium conditions, and describes the binding, linkage, and feedback phenomena that lead to control of complex metabolic processes. The first chapter sets out the different processes (conformational changes, changes in state of aggregation, phase changes) involving biological macromolecules which are affected by chemical variables (such as ligands) or physical variables (such as temperature and pressure). The general effects of ligands on micromolecular conformations and interactions are illustrated with specific examples from the respiratory proteins, electron-transport proteins, and nucleic acid binding proteins. Subsequent chapters develop these themes, and describe in detail how the mathematics of regulation and control can be applied to macromolecules in biological system.

Binding Phenomena

2023-11-21 Science
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Release : 2023-11-21
Genre : Science
Kind : eBook
Book Rating : 363/5 ( reviews)

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Book Synopsis Binding Phenomena by : Waldemar A. Marmisollé

Download or read book Binding Phenomena written by Waldemar A. Marmisollé. This book was released on 2023-11-21. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a unified description of binding equilibrium for a wide variety of systems focusing on acid-base and coordination chemistry, adsorption at interfaces, and electron binding in electrochemistry. It overviews more complex phenomena such as competitive binding to different sites and of different ligands. Multiple sites such as those occurring in macromolecules, colloidal oxides, humid substances, and proteins are briefly discussed and many experimental results for these types of systems are analyzed. Titrations and consideration of the distribution of binding constants are also presented. The book is mainly directed at undergraduate/graduate students of chemistry, biology, and earth sciences. It is supplementary to the standard physical and analytical chemistry courses and will help both students and teachers get a more in-depth knowledge and understanding of the systems analyzed.

Linkage Thermodynamics of Macromolecular Interactions

1998-06-24 Science
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Release : 1998-06-24
Genre : Science
Kind : eBook
Book Rating : 249/5 ( reviews)

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Book Synopsis Linkage Thermodynamics of Macromolecular Interactions by :

Download or read book Linkage Thermodynamics of Macromolecular Interactions written by . This book was released on 1998-06-24. Available in PDF, EPUB and Kindle. Book excerpt: This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.

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