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Integrated Strategies for Drug Discovery Using Mass Spectrometry

2005-09-02 Science
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Release : 2005-09-02
Genre : Science
Kind : eBook
Book Rating : 026/5 ( reviews)

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Book Synopsis Integrated Strategies for Drug Discovery Using Mass Spectrometry by : Mike S. Lee

Download or read book Integrated Strategies for Drug Discovery Using Mass Spectrometry written by Mike S. Lee. This book was released on 2005-09-02. Available in PDF, EPUB and Kindle. Book excerpt: New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug discovery. The topicsrepresent current industry benchmarks in specific drug discoveryactivities that deal with proteomics, biomarker discovery,metabonomic approaches for toxicity screening, lead identification,compound libraries, quantitative bioanalytical support,biotransformation, reactive metabolite characterization, leadoptimization, pharmaceutical property profiling, sample preparationstrategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry areinterconnected * Discusses the uses and limitations of various types of massspectrometry in various aspects of drug discovery * Prominently features analytical applications that requiretrace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques toaid in the understanding of how and why new methods are now beingemployed to analyze samples

High-Throughput Mass Spectrometry in Drug Discovery

2023-06-29 Science
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Release : 2023-06-29
Genre : Science
Kind : eBook
Book Rating : 463/5 ( reviews)

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Book Synopsis High-Throughput Mass Spectrometry in Drug Discovery by : Chang Liu

Download or read book High-Throughput Mass Spectrometry in Drug Discovery written by Chang Liu. This book was released on 2023-06-29. Available in PDF, EPUB and Kindle. Book excerpt: High-Throughput Mass Spectrometry in Drug Discovery Apply mass spectrometry to every phase of new drug discovery with this cutting-edge guide Mass spectrometry is a technique that identifies and characterizes compounds based on their mass — the fundamental molecular characteristic. It has become an invaluable analytical tool in various disciplines, industries, and research fields. It has become particularly central to new drug discovery and development, which broadly deploys mass spectrometry at every phase. The pharmaceutical industry has become one of the main drivers of technological development in mass spectrometry. High-Throughput Mass Spectrometry in Drug Discovery offers a comprehensive introduction to mass spectrometry and its applications in pharmaceutical discovery. It covers the foundational principles and science of mass spectrometry before moving to specific experimental methods and their applications at various stages of drug discovery. Its thorough treatment and detailed guidance make it an invaluable tool for pharmaceutical research and development. High-Throughput Mass Spectrometry in Drug Discovery readers will also find: Detailed analysis of techniques, including label-free screening, synthetic reaction optimization, and more An authorial team with extensive combined experience in research and industrial applications Technical strategies with the potential to accelerate quantitative bioanalysis in drug discovery High-Throughput Mass Spectrometry in Drug Discovery is essential for analytical, bioanalytical, and medicinal chemists working in the pharmaceutical industry and for any researchers and graduate students interested in drug discovery and development.

Integrated Drug Discovery Technologies

2002-03-19 Medical
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Release : 2002-03-19
Genre : Medical
Kind : eBook
Book Rating : 696/5 ( reviews)

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Book Synopsis Integrated Drug Discovery Technologies by : Houng-Yau Mei

Download or read book Integrated Drug Discovery Technologies written by Houng-Yau Mei. This book was released on 2002-03-19. Available in PDF, EPUB and Kindle. Book excerpt: Integrated Drug Discovery Technologies provides a global overview of emerging drug development technologies by presenting and integrating new techniques from the disciplines of chemistry, biology, and computational sciences. It combines integration of contemporary mechanization with strategies in drug delivery. Topics include: functional genomics,

Protein and Peptide Mass Spectrometry in Drug Discovery

2011-09-26 Medical
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Release : 2011-09-26
Genre : Medical
Kind : eBook
Book Rating : 542/5 ( reviews)

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Book Synopsis Protein and Peptide Mass Spectrometry in Drug Discovery by : Michael L. Gross

Download or read book Protein and Peptide Mass Spectrometry in Drug Discovery written by Michael L. Gross. This book was released on 2011-09-26. Available in PDF, EPUB and Kindle. Book excerpt: The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.

Using Mass Spectrometry for Drug Metabolism Studies

2009-11-03 Medical
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Release : 2009-11-03
Genre : Medical
Kind : eBook
Book Rating : 219/5 ( reviews)

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Book Synopsis Using Mass Spectrometry for Drug Metabolism Studies by : Walter A. Korfmacher

Download or read book Using Mass Spectrometry for Drug Metabolism Studies written by Walter A. Korfmacher. This book was released on 2009-11-03. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the fiel

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