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Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing

2020-09-28 Medical
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Release : 2020-09-28
Genre : Medical
Kind : eBook
Book Rating : 214/5 ( reviews)

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Book Synopsis Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing by : Khalid El Bairi

Download or read book Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing written by Khalid El Bairi. This book was released on 2020-09-28. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the potential of next-generation sequencing (NGS) in research on and management of colorectal cancer (CRC), a leading cause of death worldwide and one of the most biologically and clinically heterogeneous cancers. It critically discusses findings from recent large-scale studies, clinical trials and meta-analyses and offers an introduction to the management of CRC in the era of precision medicine. In CRC, dozens of driver and passenger mutations are associated with the malignant transformation of epithelial cells. Consequently, the book discusses recent advances in our understanding of the genetics of CRC as a biomarker, the advent of NGS technologies in modern genomics, and the impact of NGS technology on the management of CRC. Furthermore, it highlights the potential of NGS in the context of liquid biopsy and single-cell sequencing in CRC, as well as its role in shedding light on the link between gut microbiota, immune-checkpoint blockade and CRC. The book concludes with a chapter on the limitations and cost-effectiveness of NGS in CRC. Given its scope, the book will appeal to all those interested in learning about the potential of NGS in advancing CRC research and patient care.

Next Generation Sequencing in Cancer Research, Volume 2

2015-04-25 Medical
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Release : 2015-04-25
Genre : Medical
Kind : eBook
Book Rating : 112/5 ( reviews)

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Book Synopsis Next Generation Sequencing in Cancer Research, Volume 2 by : Wei Wu

Download or read book Next Generation Sequencing in Cancer Research, Volume 2 written by Wei Wu. This book was released on 2015-04-25. Available in PDF, EPUB and Kindle. Book excerpt: Latest generation sequencing revolutionizes the fields of cancer research and oncology. This follow-up volume focuses more extensively on single cell sequencing of cancer and trials in drug resistance. Another exciting feature is the bioinformatics tools given, that can be used on cancer genome studies. Scientists around the world are attempting to find the root cause of cancer. A reasonable cancer treatment plan and potential cure is more optimistic now with the unfolding of the cancer genome. The collective knowledge of how to leverage next generation sequencing in cancer research is paving the way. The important information provided in this volume will move the field forward in developing novel targeted cancer therapies.

Cancer Genomics

2013-11-21 Medical
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Release : 2013-11-21
Genre : Medical
Kind : eBook
Book Rating : 999/5 ( reviews)

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Book Synopsis Cancer Genomics by : Hye-Jung E. Chun

Download or read book Cancer Genomics written by Hye-Jung E. Chun. This book was released on 2013-11-21. Available in PDF, EPUB and Kindle. Book excerpt: Cancer results from accumulated mutations in the genome. Sequencing is an accurate method to detect mutations. Second-generation sequencing technology, commonly referred to as next-generation sequencing technology, enables rapid, efficient and affordable DNA sequencing, and is transforming the scale and scope of cancer research. The technology is sufficiently flexible and affordable to allow sequencing of many cancer genomes, and thus facilitates both sequencing of samples from large patient cohorts and during disease progression in individual cancer patients. The high depths of redundant sequence coverage that can be obtained using some second-generation sequencing technologies, along with sequencing reads amplified from single DNA molecules, facilitate detection of subclones of cells in tumors. Large-scale genome sequencing of hundreds or even thousands of cancer samples is being conducted by several groups that aim to identify and characterize cancer driver mutations. Goals of such work, previously infeasible with Sanger sequencing instruments, are to use this information to improve cancer prognosis, diagnosis and therapeutic decision-making. The speed of data analysis is rate limiting, and investigators are struggling to accommodate and interpret the data deluge produced by second-generation technologies. In this chapter, we discuss cancer properties that are revealed by sequencing and the implication of such properties in experimental design and data interpretation. We describe past, current and upcoming sequencing technologies and the application of second-generation sequencing technologies in cancer genomics. Finally, we discuss the impact of second-generation sequencing technology in shaping personalized medicine.

Next Generation Sequencing Based Diagnostic Approaches in Clinical Oncology

2021-03-09 Science
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Release : 2021-03-09
Genre : Science
Kind : eBook
Book Rating : 755/5 ( reviews)

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Book Synopsis Next Generation Sequencing Based Diagnostic Approaches in Clinical Oncology by : Anton A. Buzdin

Download or read book Next Generation Sequencing Based Diagnostic Approaches in Clinical Oncology written by Anton A. Buzdin. This book was released on 2021-03-09. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Anton Buzdin (AB) is employed by Omicsway Corp. (USA). AB received grants from Amazon and Microsoft Azure to support cloud computations. Dr. Xinmin Li is director of JCCC Shared Genomics Resource, the University of California, Los Angeles, CA Dr. Ye Wang is Director of Gene testing Department (Core Lab) of Qingdao Central Hospital, the Second Affiliated Hospital of Qingdao University

Next Generation Sequencing in Cancer Research

2013-08-04 Medical
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Release : 2013-08-04
Genre : Medical
Kind : eBook
Book Rating : 453/5 ( reviews)

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Book Synopsis Next Generation Sequencing in Cancer Research by : Wei Wu

Download or read book Next Generation Sequencing in Cancer Research written by Wei Wu. This book was released on 2013-08-04. Available in PDF, EPUB and Kindle. Book excerpt: ​​​​This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology.

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