Histamine in the brain

2015-03-18 Brain

Author : Jian-Sheng Lin
Release : 2015-03-18
Genre : Brain
Kind : eBook
Book Rating : 345/5 ( reviews)

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Book Synopsis Histamine in the brain by : Jian-Sheng Lin

Download or read book Histamine in the brain written by Jian-Sheng Lin. This book was released on 2015-03-18. Available in PDF, EPUB and Kindle. Book excerpt: Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.

Histamine in Inflammation

2011-06-29 Medical

Author : Robin Thurmond
Release : 2011-06-29
Genre : Medical
Kind : eBook
Book Rating : 563/5 ( reviews)

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Book Synopsis Histamine in Inflammation by : Robin Thurmond

Download or read book Histamine in Inflammation written by Robin Thurmond. This book was released on 2011-06-29. Available in PDF, EPUB and Kindle. Book excerpt: The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.

Itch

2014-02-25 Science

Author : E. Carstens
Release : 2014-02-25
Genre : Science
Kind : eBook
Book Rating : 435/5 ( reviews)

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Book Synopsis Itch by : E. Carstens

Download or read book Itch written by E. Carstens. This book was released on 2014-02-25. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Histamine Receptors

2016-11-07 Medical

Author : Patrizio Blandina
Release : 2016-11-07
Genre : Medical
Kind : eBook
Book Rating : 087/5 ( reviews)

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Book Synopsis Histamine Receptors by : Patrizio Blandina

Download or read book Histamine Receptors written by Patrizio Blandina. This book was released on 2016-11-07. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation.

Histaminergic Neurons

1991-02-22 Science

Author : Takehiko Watanabe
Release : 1991-02-22
Genre : Science
Kind : eBook
Book Rating : 259/5 ( reviews)

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Book Synopsis Histaminergic Neurons by : Takehiko Watanabe

Download or read book Histaminergic Neurons written by Takehiko Watanabe. This book was released on 1991-02-22. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview on the histaminergic neuron system in the brain for neuroscience, anatomy, pharmacology, biochemistry, and medical researchers. Topics discussed include the biochemistry of enzymes; histamine receptors (H1, H2, and H3); morphology, coexistance, and development of the histaminergic neuron system; electrophysiological studies on vertebrate and invertebrate neurons; as well as the functions of the histamine neurons.

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Histamine in the brain

Histamine in Inflammation

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