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Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors

2006-11-17 Science
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Release : 2006-11-17
Genre : Science
Kind : eBook
Book Rating : 155/5 ( reviews)

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Book Synopsis Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors by : Ana Martinez

Download or read book Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors written by Ana Martinez. This book was released on 2006-11-17. Available in PDF, EPUB and Kindle. Book excerpt: Many researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity. It’s a great reference for researchers in drug design and development.

Molecules to Medicine with mTOR

2016-02-21 Science
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Release : 2016-02-21
Genre : Science
Kind : eBook
Book Rating : 55X/5 ( reviews)

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Book Synopsis Molecules to Medicine with mTOR by : Kenneth Maiese

Download or read book Molecules to Medicine with mTOR written by Kenneth Maiese. This book was released on 2016-02-21. Available in PDF, EPUB and Kindle. Book excerpt: Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin. - Covers the role of mTOR by internationally recognized expert contributors in the field. - Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels. - Includes analysis of the role of mTOR and in both health and disease. - Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.

Protein Kinases in Development and Disease

2017-02-22 Science
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Release : 2017-02-22
Genre : Science
Kind : eBook
Book Rating : 248/5 ( reviews)

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Book Synopsis Protein Kinases in Development and Disease by :

Download or read book Protein Kinases in Development and Disease written by . This book was released on 2017-02-22. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinases in Development and Disease discusses and reviews important, but often neglected, kinases. A good representation of current model organisms from plants and C. elegans to mice are used as the basis to illustrate how we can use our understanding of normal development to learn about disease. - Reviews kinases, the fundamental regulators of most biological processes that have key roles in the development of all organisms - Includes a broad scope of topics that are addressed - Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge

Epigenetics in Psychiatry

2021-08-21 Science
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Release : 2021-08-21
Genre : Science
Kind : eBook
Book Rating : 780/5 ( reviews)

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Book Synopsis Epigenetics in Psychiatry by : Jacob Peedicayil

Download or read book Epigenetics in Psychiatry written by Jacob Peedicayil. This book was released on 2021-08-21. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. - Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease - Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins - Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery - Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) - Features chapter contributions from international leaders in the field

Glycogen Synthase Kinases—Advances in Research and Application: 2012 Edition

2012-12-26 Medical
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Release : 2012-12-26
Genre : Medical
Kind : eBook
Book Rating : 687/5 ( reviews)

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Book Synopsis Glycogen Synthase Kinases—Advances in Research and Application: 2012 Edition by :

Download or read book Glycogen Synthase Kinases—Advances in Research and Application: 2012 Edition written by . This book was released on 2012-12-26. Available in PDF, EPUB and Kindle. Book excerpt: Glycogen Synthase Kinases—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Glycogen Synthase Kinases in a concise format. The editors have built Glycogen Synthase Kinases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Glycogen Synthase Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Glycogen Synthase Kinases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

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