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Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

2011-08-05 Medical
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Release : 2011-08-05
Genre : Medical
Kind : eBook
Book Rating : 219/5 ( reviews)

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Book Synopsis Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by : Institute of Medicine

Download or read book Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System written by Institute of Medicine. This book was released on 2011-08-05. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

2011-07-05
Download Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System PDF Online Free

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Release : 2011-07-05
Genre :
Kind : eBook
Book Rating : 628/5 ( reviews)

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Book Synopsis Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by : Forum on Neuroscience and Nervous System Disorders

Download or read book Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System written by Forum on Neuroscience and Nervous System Disorders. This book was released on 2011-07-05. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Download Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System PDF Online Free

Author :
Release :
Genre :
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by :

Download or read book Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System written by . This book was released on . Available in PDF, EPUB and Kindle. Book excerpt:

Improving and Accelerating Therapeutic Development for Nervous System Disorders

2014-02-06 Medical
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Release : 2014-02-06
Genre : Medical
Kind : eBook
Book Rating : 492/5 ( reviews)

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Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine

Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine. This book was released on 2014-02-06. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Glutamate-Related Biomarkers for Neuropsychiatric Disorders

2020-01-15
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Release : 2020-01-15
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Book Rating : 799/5 ( reviews)

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Book Synopsis Glutamate-Related Biomarkers for Neuropsychiatric Disorders by : Hsien-Yuan Lane

Download or read book Glutamate-Related Biomarkers for Neuropsychiatric Disorders written by Hsien-Yuan Lane. This book was released on 2020-01-15. Available in PDF, EPUB and Kindle. Book excerpt:

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