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Genomes, Browsers and Databases

2008-06-16 Science
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Release : 2008-06-16
Genre : Science
Kind : eBook
Book Rating : 712/5 ( reviews)

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Book Synopsis Genomes, Browsers and Databases by : Peter Schattner

Download or read book Genomes, Browsers and Databases written by Peter Schattner. This book was released on 2008-06-16. Available in PDF, EPUB and Kindle. Book excerpt: The recent explosive growth of biological data has lead to a rapid increase in the number of molecular biology databases. Held in many different locations and often using varying interfaces and non-standard data formats, integrating and comparing data from these multiple databases can be difficult and time-consuming. This book provides an overview of the key tools currently available for large-scale comparisons of gene sequences and annotations, focusing on the databases and tools from the University of California, Santa Cruz (UCSC), Ensembl, and the National Centre for Biotechnology Information (NCBI). Written specifically for biology and bioinformatics students and researchers, it aims to give an appreciation of the methods by which the browsers and their databases are constructed, enabling readers to determine which tool is the most appropriate for their requirements. Each chapter contains a summary and exercises to aid understanding and promote effective use of these important tools.

Vogel and Motulsky's Human Genetics

2009-11-26 Medical
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Release : 2009-11-26
Genre : Medical
Kind : eBook
Book Rating : 542/5 ( reviews)

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Book Synopsis Vogel and Motulsky's Human Genetics by : Michael Speicher

Download or read book Vogel and Motulsky's Human Genetics written by Michael Speicher. This book was released on 2009-11-26. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of this classical reference book can once again be relied upon to present a cohesive and up-to-date exposition of all aspects of human and medical genetics. Human genetics has become one of the main basic sciences in medicine, and molecular genetics is increasingly becoming a major part of this field. This new edition integrates a wealth of new information - mainly describing the influence of the "molecular revolution" - including the principles of epigenetic processes which together create the phenotype of a human being. Other revisions are an improved layout, sub-division into a larger number of chapters, as well as two-colour print throughout for ease of reference, and many of the figures are now in full colour. For graduates and those already working in medical genetics.

Genome Annotation

2016-04-19 Science
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Release : 2016-04-19
Genre : Science
Kind : eBook
Book Rating : 187/5 ( reviews)

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Book Synopsis Genome Annotation by : Jung Soh

Download or read book Genome Annotation written by Jung Soh. This book was released on 2016-04-19. Available in PDF, EPUB and Kindle. Book excerpt: The success of individualized medicine, advanced crops, and new and sustainable energy sources requires thoroughly annotated genomic information and the integration of this information into a coherent model. A thorough overview of this field, Genome Annotation explores automated genome analysis and annotation from its origins to the challenges of next-generation sequencing data analysis. The book initially takes you through the last 16 years since the sequencing of the first complete microbial genome. It explains how current analysis strategies were developed, including sequencing strategies, statistical models, and early annotation systems. The authors then present visualization techniques for displaying integrated results as well as state-of-the-art annotation tools, including MAGPIE, Ensembl, Bluejay, and Galaxy. They also discuss the pipelines for the analysis and annotation of complex, next-generation DNA sequencing data. Each chapter includes references and pointers to relevant tools. As very few existing genome annotation pipelines are capable of dealing with the staggering amount of DNA sequence information, new strategies must be developed to accommodate the needs of today’s genome researchers. Covering this topic in detail, Genome Annotation provides you with the foundation and tools to tackle this challenging and evolving area. Suitable for both students new to the field and professionals who deal with genomic information in their work, the book offers two genome annotation systems on an accompanying CD-ROM.

Eukaryotic Genomic Databases

2019-05-29 Medical
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Release : 2019-05-29
Genre : Medical
Kind : eBook
Book Rating : 706/5 ( reviews)

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Book Synopsis Eukaryotic Genomic Databases by : Martin Kollmar

Download or read book Eukaryotic Genomic Databases written by Martin Kollmar. This book was released on 2019-05-29. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores databases containing genome-based data and genome-wide analyses. This book covers databases from all eukaryotic taxa, except plants. The chapters describe database contents and classic use-cases, which assist in accessing eukaryotic genomic data and encouraging comparative genomic research. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Eukaryotic Genomic Databases: Methods and Protocols is a valuable resource for geneticists and molecular biologists who are interested in the latest eukaryotic genomics data. The chapters 'PomBase: The Scientific Resource for Fission Yeast' and 'The Ensembl Genome Browser: Strategies for Accessing Eukaryotic Genome Data' are available open access under a CC BY 4.0 license via link.springer.com.

Genome Data Analysis

2019-04-30 Science
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Release : 2019-04-30
Genre : Science
Kind : eBook
Book Rating : 421/5 ( reviews)

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Book Synopsis Genome Data Analysis by : Ju Han Kim

Download or read book Genome Data Analysis written by Ju Han Kim. This book was released on 2019-04-30. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes recent advances in genomics and bioinformatics and provides numerous examples of genome data analysis that illustrate its relevance to real world problems and will improve the reader’s bioinformatics skills. Basic data preprocessing with normalization and filtering, primary pattern analysis, and machine learning algorithms using R and Python are demonstrated for gene-expression microarrays, genotyping microarrays, next-generation sequencing data, epigenomic data, and biological network and semantic analyses. In addition, detailed attention is devoted to integrative genomic data analysis, including multivariate data projection, gene-metabolic pathway mapping, automated biomolecular annotation, text mining of factual and literature databases, and integrated management of biomolecular databases. The textbook is primarily intended for life scientists, medical scientists, statisticians, data processing researchers, engineers, and other beginners in bioinformatics who are experiencing difficulty in approaching the field. However, it will also serve as a simple guideline for experts unfamiliar with the new, developing subfield of genomic analysis within bioinformatics.

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