Genetics of Human Infertility

2017-09-12 Medical

Author : P.H. Vogt
Release : 2017-09-12
Genre : Medical
Kind : eBook
Book Rating : 984/5 ( reviews)

Book Synopsis Genetics of Human Infertility by : P.H. Vogt

Download or read book Genetics of Human Infertility written by P.H. Vogt. This book was released on 2017-09-12. Available in PDF, EPUB and Kindle. Book excerpt: Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.

The Genetics of Male Infertility

2007-11-08 Medical

Author : Douglas T. Carrell
Release : 2007-11-08
Genre : Medical
Kind : eBook
Book Rating : 762/5 ( reviews)

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Book Synopsis The Genetics of Male Infertility by : Douglas T. Carrell

Download or read book The Genetics of Male Infertility written by Douglas T. Carrell. This book was released on 2007-11-08. Available in PDF, EPUB and Kindle. Book excerpt: In this book, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. New tools discussed are discussed. This book therefore serves as a guide to evidence-based clinical applications, and a preview of future possibilities.

Textbook of Human Reproductive Genetics

2014-04-10 Medical

Author : Karen Sermon
Release : 2014-04-10
Genre : Medical
Kind : eBook
Book Rating : 580/5 ( reviews)

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Book Synopsis Textbook of Human Reproductive Genetics by : Karen Sermon

Download or read book Textbook of Human Reproductive Genetics written by Karen Sermon. This book was released on 2014-04-10. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together genetics, reproductive biology and medicine for an integrative view of the emerging specialism of reproductive genetics.

Genetics of Male Infertility

2020-03-14 Health & Fitness

Author : Mohamed Arafa
Release : 2020-03-14
Genre : Health & Fitness
Kind : eBook
Book Rating : 728/5 ( reviews)

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Book Synopsis Genetics of Male Infertility by : Mohamed Arafa

Download or read book Genetics of Male Infertility written by Mohamed Arafa. This book was released on 2020-03-14. Available in PDF, EPUB and Kindle. Book excerpt: This unique, case-based guide provides a thoughtful and comprehensive overview of the genetic basis of male infertility for the practicing clinician. In addition to discussing the molecular foundations of sperm production and the consequences of genetic abnormalities on various stages of sperm development, it examines the clinical aspects of acknowledged genetic disorders and their implications on male fertility. In so doing, it offers the necessary tools required by the clinician for the diagnosis and treatment of infertile men with genetic abnormalities. Moreover, it provides essential algorithms that may aid in counseling patients in the clinic. The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2, covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing. Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.

Human Reproductive and Prenatal Genetics

2023-03-22 Science

Author : Peter C.K. Leung
Release : 2023-03-22
Genre : Science
Kind : eBook
Book Rating : 814/5 ( reviews)

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Book Synopsis Human Reproductive and Prenatal Genetics by : Peter C.K. Leung

Download or read book Human Reproductive and Prenatal Genetics written by Peter C.K. Leung. This book was released on 2023-03-22. Available in PDF, EPUB and Kindle. Book excerpt: Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic. This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications. Features chapter contributions from leading international scientists and clinicians Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization, placental development, embryo implantation, in vitro culture of the human embryo for the study of post-implantation development, and more Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and –omics-based approaches Includes all new chapters on evolving technologies and recent genetic discoveries of relevance to reproductive medicine

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