Author : Jeffrey V. Ravetch
Release : 2019-09-03
Genre : Medical
Kind : eBook
Book Rating : 531/5 ( reviews)
Book Synopsis Fc Mediated Activity of Antibodies by : Jeffrey V. Ravetch
Download or read book Fc Mediated Activity of Antibodies written by Jeffrey V. Ravetch. This book was released on 2019-09-03. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.