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Epigenetic Targets in Drug Discovery

2009-08-03 Medical
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Release : 2009-08-03
Genre : Medical
Kind : eBook
Book Rating : 555/5 ( reviews)

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Book Synopsis Epigenetic Targets in Drug Discovery by : Wolfgang Sippl

Download or read book Epigenetic Targets in Drug Discovery written by Wolfgang Sippl. This book was released on 2009-08-03. Available in PDF, EPUB and Kindle. Book excerpt: Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease. The first part of the book surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms. The second part systematically surveys known and suspected drug targets within the epigenetic machinery, including the discovery and development of vorinostat, the first marketed epigenetic drug.

Epigenetic Drug Discovery

2019-03-25 Medical
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Release : 2019-03-25
Genre : Medical
Kind : eBook
Book Rating : 148/5 ( reviews)

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Book Synopsis Epigenetic Drug Discovery by : Wolfgang Sippl

Download or read book Epigenetic Drug Discovery written by Wolfgang Sippl. This book was released on 2019-03-25. Available in PDF, EPUB and Kindle. Book excerpt: This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and molecular geneticists.

Epigenetics for Drug Discovery

2015-11-20 Medical
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Release : 2015-11-20
Genre : Medical
Kind : eBook
Book Rating : 823/5 ( reviews)

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Book Synopsis Epigenetics for Drug Discovery by : Nessa Carey

Download or read book Epigenetics for Drug Discovery written by Nessa Carey. This book was released on 2015-11-20. Available in PDF, EPUB and Kindle. Book excerpt: This book will provide an invaluable guide to epigenetics, one of the fastest moving fields in drug discovery, for medicinal chemists working in academia and in the pharmaceutical industry.

Drug Discovery in Cancer Epigenetics

2015-11-19 Science
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Release : 2015-11-19
Genre : Science
Kind : eBook
Book Rating : 925/5 ( reviews)

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Book Synopsis Drug Discovery in Cancer Epigenetics by : Gerda Egger

Download or read book Drug Discovery in Cancer Epigenetics written by Gerda Egger. This book was released on 2015-11-19. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. Highlights the potential of epigenetic alterations in cancer for drug development Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation

Structural Biology in Drug Discovery

2020-01-09 Medical
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Release : 2020-01-09
Genre : Medical
Kind : eBook
Book Rating : 502/5 ( reviews)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud. This book was released on 2020-01-09. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

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