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Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Bloodâ¬"Brain Barrier

2018-06-29 Medical
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Release : 2018-06-29
Genre : Medical
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Book Rating : 071/5 ( reviews)

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Book Synopsis Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Bloodâ¬"Brain Barrier by : National Academies of Sciences, Engineering, and Medicine

Download or read book Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Bloodâ¬"Brain Barrier written by National Academies of Sciences, Engineering, and Medicine. This book was released on 2018-06-29. Available in PDF, EPUB and Kindle. Book excerpt: Despite substantial advances in developing treatments for the serious illnesses that affect people worldwide, there remains a tremendous unmet need in the treatment of complex neurologic diseases, including neuropsychiatric and neurodegenerative disorders. Chief among the challenges that have hindered the development of therapeutics for central nervous system (CNS) disorders is the bloodâ€"brain barrier (BBB). The Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop to explore the challenges associated with the BBB that have thus far stymied development of CNS drugs, examine new technologies that could address these challenges, and highlight potential opportunities for moving the field forward. This publication summarizes the presentations and discussions from the workshop.

Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Blood-Brain Barrier

2018
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Release : 2018
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Book Synopsis Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Blood-Brain Barrier by :

Download or read book Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Blood-Brain Barrier written by . This book was released on 2018. Available in PDF, EPUB and Kindle. Book excerpt:

Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Bloodђ́أBrain Barrier: Proceedings of a Workshop

2018
Download Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Bloodђ́أBrain Barrier: Proceedings of a Workshop PDF Online Free

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Release : 2018
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Book Synopsis Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Bloodђ́أBrain Barrier: Proceedings of a Workshop by :

Download or read book Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Bloodђ́أBrain Barrier: Proceedings of a Workshop written by . This book was released on 2018. Available in PDF, EPUB and Kindle. Book excerpt:

Drug-induced Neurological Disorders

2021-07-13 Medical
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Release : 2021-07-13
Genre : Medical
Kind : eBook
Book Rating : 036/5 ( reviews)

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Book Synopsis Drug-induced Neurological Disorders by : Kewal K. Jain

Download or read book Drug-induced Neurological Disorders written by Kewal K. Jain. This book was released on 2021-07-13. Available in PDF, EPUB and Kindle. Book excerpt: This book is a first-of-its kind reference that systematically organizes and describes the adverse effects of drugs on the nervous system. Drug safety is recognized as an important aspect of pharmaceutical companies as well as practice of medicine. Chapters include case reports of adverse effects of drugs that are published as well as reported to drug manufacturers. The book scope is broad as it covers lack of efficacy, drug resistance, drug-disease and drug-drug interactions. This information is used to improve the use of drugs as well as to design better and safer drugs for the future, and is relevant to personalized medicine in trying to match the right drugs to the patients. Drug-induced Neurological Disorders offers a unique approach to this important topic by integrating clinical neurology with pharmacology with a focus on effects of drugs on the nervous system including those used for the treatment of neurological disorders as well systemic diseases. Many adverse effects involve multiple systems of the body and the syndromes with predominant effect on the nervous system are included in this book.

Improving and Accelerating Therapeutic Development for Nervous System Disorders

2014-02-06 Medical
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Release : 2014-02-06
Genre : Medical
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Book Rating : 492/5 ( reviews)

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Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine

Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine. This book was released on 2014-02-06. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

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