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Author : Daniel Gerlich
Release : 2002
Genre :
Kind : eBook
Book Rating : /5 ( reviews)
Book Synopsis Dynamics of Nuclear Architecture Investigated by Live Cell Microscopy and Quantitative 4-D Reconstruction by : Daniel Gerlich
Download or read book Dynamics of Nuclear Architecture Investigated by Live Cell Microscopy and Quantitative 4-D Reconstruction written by Daniel Gerlich. This book was released on 2002. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christophe Lavelle
Release : 2017-10-27
Genre : Science
Kind : eBook
Book Rating : 03X/5 ( reviews)
Book Synopsis Nuclear Architecture and Dynamics by : Christophe Lavelle
Download or read book Nuclear Architecture and Dynamics written by Christophe Lavelle. This book was released on 2017-10-27. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines. - Highlights the link between the (bio)chemistry and the (bio)physics of chromatin - Deciphers the complex interplay between numerous biochemical factors at task in the nucleus and the physical state of chromatin - Provides a collective view of the field by a large, diverse group of authors with both physics and biology backgrounds
Author :
Release : 2003
Genre :
Kind : eBook
Book Rating : /5 ( reviews)
Book Synopsis Modelling Nuclear Body Dynamics in Living Cells by 4-D Microscopy, Image Analysis and Simulation by :
Download or read book Modelling Nuclear Body Dynamics in Living Cells by 4-D Microscopy, Image Analysis and Simulation written by . This book was released on 2003. Available in PDF, EPUB and Kindle. Book excerpt: The work presented here demonstrates rules of and validates models for nuclear body (NB) dynamics. Simulation tools developed in the course of this work can be used in future work to generate hypotheses about related aspects of nuclear architecture. Initially I examined the mobility of vimentin nuclear bodies bodies (VNB) in interphase by single particle tracking and analysis of fluorescence images from 4-D confocal laser scanning microscopy (CLSM). These synthetic nuclear bodies are observed in cells transfected with labelled nuclear-targeted Xenopus laevis vimentin. Analysis shows that VNBs undergo anomalous diffusion in the nuclei, independent of metabolic energy. Individual bodies display either one of the three modes of diffusion -- directed, restricted or simple. The consistency of modes and magnitudes of diffusion constants between VNBs and bona fide nuclear bodies points to a generic mechanism that mediates and regulates the mobility of nuclear bodies. Since the results of diffusion analysis of VNBs did not agree with a simple diffusion model, I tested the alternative interchromosomal domain (ICD) compartment model. The ICD model predicts that in interphase cell nuclei, individual decompacted chromosomes do not intermingle, but are separated by a significant interchromatin space forming a network of channels. These networks could affect the mobility of nuclear bodies. Monte Carlo simulations that predict the effects of channels and other obstructions on NB diffusion were tested, but they could not explain deviation from ideal behaviour. Fitting an empirical model of `critical diffusion' produced similar results. Therefore the ICD model as a purely obstructing network of channels needs modification, to possibly include binding. To examine the role of chromatin density in intra-nuclear diffusion, I employed multidimensional fluorescence recovery after photobleaching (FRAP) in living cells. The influence of chromatin density on diffusive mobility of the nuclear.
Author : Niall M. Adams
Release : 2010-10-17
Genre : Medical
Kind : eBook
Book Rating : 992/5 ( reviews)
Book Synopsis Advances in Nuclear Architecture by : Niall M. Adams
Download or read book Advances in Nuclear Architecture written by Niall M. Adams. This book was released on 2010-10-17. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a snapshot of the state-of-the art in the study of mammalian cell nuclear architecture, and features a diverse range of chapters written by top researchers. A key aspect is an emphasis on precise and repeatable quantitative analysis and simulation in addition to the more familiar biological perspective. The fusion of such material frames the future of the discipline. Quantitative contributions stress reproducible and robust 3D analysis, using a variety of tools ranging from point pattern analysis to shape registration methods. Biological insights include the role of nuclear subdomains in cancer, nuclear molecular motors, and a holistic view of gene transcription.
Author : K. Nagata
Release : 2007-12-03
Genre : Science
Kind : eBook
Book Rating : 305/5 ( reviews)
Book Synopsis Nuclear Dynamics by : K. Nagata
Download or read book Nuclear Dynamics written by K. Nagata. This book was released on 2007-12-03. Available in PDF, EPUB and Kindle. Book excerpt: The dynamics of nuclear structures described in this book furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.
