Drug Targets in Cellular Processes of Cancer: From Nonclinical to Preclinical Models

2020-09-30 Medical

Author : Hardeep Singh Tuli
Release : 2020-09-30
Genre : Medical
Kind : eBook
Book Rating : 86X/5 ( reviews)

GET EBOOK

Book Synopsis Drug Targets in Cellular Processes of Cancer: From Nonclinical to Preclinical Models by : Hardeep Singh Tuli

Download or read book Drug Targets in Cellular Processes of Cancer: From Nonclinical to Preclinical Models written by Hardeep Singh Tuli. This book was released on 2020-09-30. Available in PDF, EPUB and Kindle. Book excerpt: This book explores potential cellular drug targets for cancer therapy. The first couple of chapters describe conventional treatment (radiotherapy, chemotherapy, and immunotherapy) & detection (biosensors) strategies for cancer. In contrast, the subsequent chapters address the role of cyclin-dependent kinases and cell cycle regulatory proteins in the growth of cancer cells and their potential as target for cancer treatment. The book then discusses the regulation of various pro-apoptotic and anti-apoptotic proteins via chemotherapeutic drugs. In addition, it examines the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells. It subsequently reviews the role of reactive oxygen (ROS) species during carcinogenesis and during chemotherapy, and the potential of anti-inflammatory routes for the development of new therapeutic modulators. Lastly, it describes therapeutic strategies that target the tumor microenvironment and various angiogenic pathways for the treatment of cancer and to develop personalized medicine. Given its scope, the book is valuable resource for oncologists, cancer researchers, clinicians, and pharmaceutical industry personnel.

Tumor Organoids

2017-10-20 Medical

Author : Shay Soker
Release : 2017-10-20
Genre : Medical
Kind : eBook
Book Rating : 119/5 ( reviews)

GET EBOOK

Book Synopsis Tumor Organoids by : Shay Soker

Download or read book Tumor Organoids written by Shay Soker. This book was released on 2017-10-20. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Anticancer Drug Development Guide

2004-02-01 Medical

Author : Beverly A. Teicher
Release : 2004-02-01
Genre : Medical
Kind : eBook
Book Rating : 394/5 ( reviews)

GET EBOOK

Book Synopsis Anticancer Drug Development Guide by : Beverly A. Teicher

Download or read book Anticancer Drug Development Guide written by Beverly A. Teicher. This book was released on 2004-02-01. Available in PDF, EPUB and Kindle. Book excerpt: This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.

Drug Discovery Toxicology

2016-04-18 Medical

Author : Yvonne Will
Release : 2016-04-18
Genre : Medical
Kind : eBook
Book Rating : 331/5 ( reviews)

GET EBOOK

Book Synopsis Drug Discovery Toxicology by : Yvonne Will

Download or read book Drug Discovery Toxicology written by Yvonne Will. This book was released on 2016-04-18. Available in PDF, EPUB and Kindle. Book excerpt: As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Antibody-Drug Conjugates

2016-11-14 Medical

Author : Kenneth J. Olivier, Jr.
Release : 2016-11-14
Genre : Medical
Kind : eBook
Book Rating : 842/5 ( reviews)

GET EBOOK

Book Synopsis Antibody-Drug Conjugates by : Kenneth J. Olivier, Jr.

Download or read book Antibody-Drug Conjugates written by Kenneth J. Olivier, Jr.. This book was released on 2016-11-14. Available in PDF, EPUB and Kindle. Book excerpt: Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development

Popular eBooks

Drug Targets in Cellular Processes of Cancer: From Nonclinical to Preclinical Models

Tumor Organoids

Anticancer Drug Development Guide

Drug Discovery Toxicology

Antibody-Drug Conjugates

You may also like...