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Drug Discovery and Evaluation: Pharmacological Assays

2002-06-13 Medical
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Release : 2002-06-13
Genre : Medical
Kind : eBook
Book Rating : 966/5 ( reviews)

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Book Synopsis Drug Discovery and Evaluation: Pharmacological Assays by : Hans G. Vogel

Download or read book Drug Discovery and Evaluation: Pharmacological Assays written by Hans G. Vogel. This book was released on 2002-06-13. Available in PDF, EPUB and Kindle. Book excerpt: Now expanded and updated to include molecular biology and genetic engineering techniques. The second edition of this successful reference book contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. The enclosed and fully searchable CD ROM allows easy identification of specific tests. An appendix with up-to-date guidelines and legal regulations for animal experiments in various countries will help the reader to plan experiments more effectively.

Drug Discovery and Evaluation: Pharmacological Assays

2007-10-30 Medical
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Release : 2007-10-30
Genre : Medical
Kind : eBook
Book Rating : 200/5 ( reviews)

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Book Synopsis Drug Discovery and Evaluation: Pharmacological Assays by : Hans Vogel

Download or read book Drug Discovery and Evaluation: Pharmacological Assays written by Hans Vogel. This book was released on 2007-10-30. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.

Drug Discovery and Evaluation

1997-04-09 Medical
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Release : 1997-04-09
Genre : Medical
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Drug Discovery and Evaluation by : Hans G. Vogel

Download or read book Drug Discovery and Evaluation written by Hans G. Vogel. This book was released on 1997-04-09. Available in PDF, EPUB and Kindle. Book excerpt: This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.

Drug Discovery and Evaluation: Pharmacological Assays

2015-11-14 Medical
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Release : 2015-11-14
Genre : Medical
Kind : eBook
Book Rating : 912/5 ( reviews)

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Book Synopsis Drug Discovery and Evaluation: Pharmacological Assays by : Franz J. Hock

Download or read book Drug Discovery and Evaluation: Pharmacological Assays written by Franz J. Hock. This book was released on 2015-11-14. Available in PDF, EPUB and Kindle. Book excerpt: The 4th edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal and immunomodulatory activities. Each of the more than 1,000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described. For this 4th edition, all existing chapters have been revised and completely updated. A large number of assays were added. Sections that have been specifically enlarged include - Pharmacological assays in thrombosis and haemostasis, - Antidiabetic activity (includes completely new chapters such as Biochemical Methods in Diabetology), - Anti-atherosclerotic activity. New chapters are added such as Auditory Pharmacology, Oncology Activity, Stem Cells, Omics, Personalized Medicine, etc.

Drug Discovery and Evaluation: Methods in Clinical Pharmacology

2010-12-15 Medical
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Release : 2010-12-15
Genre : Medical
Kind : eBook
Book Rating : 905/5 ( reviews)

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Book Synopsis Drug Discovery and Evaluation: Methods in Clinical Pharmacology by : H.Gerhard Vogel

Download or read book Drug Discovery and Evaluation: Methods in Clinical Pharmacology written by H.Gerhard Vogel. This book was released on 2010-12-15. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".

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