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Author : Ali Ghavami
Release : 2014
Genre :
Kind : eBook
Book Rating : 385/5 ( reviews)
Book Synopsis Coarse-grained Molecular Dynamics Simulation of Transport Through the Nuclear Pore Complex by : Ali Ghavami
Download or read book Coarse-grained Molecular Dynamics Simulation of Transport Through the Nuclear Pore Complex written by Ali Ghavami. This book was released on 2014. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chad Gu
Release : 2019
Genre :
Kind : eBook
Book Rating : /5 ( reviews)
Book Synopsis Coarse-grained Theory and Simulation of Assemblies of Intrinsically-disordered Nucleoporins by : Chad Gu
Download or read book Coarse-grained Theory and Simulation of Assemblies of Intrinsically-disordered Nucleoporins written by Chad Gu. This book was released on 2019. Available in PDF, EPUB and Kindle. Book excerpt: Selective import and export through the nuclear envelope in the eukaryotic cell is solely regulated by the transporter known as Nuclear Pore Complex (NPC). The transport conduit of the NPC is occupied by intrinsically-disordered nuclear pore proteins collectively known as FG nucleoporins, which confer selectivity to the pore, hindering the passage of large, neutral molecules while facilitating the translocation of cargos recognized by carriers known as transport proteins. Currently, the mechanism of selectivity and permeability behaviour of the NPC is a subject of intense research, though much of our understanding of the NPC is based on inferences from experiments on in vitro assemblies of FG nucleoporins, requiring rigorous analysis through a theoretical framework. In this thesis, employing approaches based on mean field theory and numerical simulations, I investigate the behaviours of in vitro assemblies of FG nucleoporins under conditions commonly studied in experiments. The models studied in this thesis depend on the most important interaction and geometric parameters of the system, but are capable of providing semi-quantitative descriptions of experimental results. In addition, these models provide the means to characterize the effective interactions between the FG nucleoporin assemblies and transport proteins, and translate equilibrium measurements of these interactions into the dynamics of transport. In all types of FG nucleoporin assemblies, different entropic and enthalpic effects stemming from molecular interactions determine the affinity between FG nucleoporin and transport proteins, demonstrating the physics of the in vitro assemblies that are expected to arise in the NPC.
Author : Reiner Peters
Release : 2012-12-06
Genre : Science
Kind : eBook
Book Rating : 656/5 ( reviews)
Book Synopsis Nucleocytoplasmic Transport by : Reiner Peters
Download or read book Nucleocytoplasmic Transport written by Reiner Peters. This book was released on 2012-12-06. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Weidong Yang
Release : 2018-07-27
Genre : Science
Kind : eBook
Book Rating : 097/5 ( reviews)
Book Synopsis Nuclear-Cytoplasmic Transport by : Weidong Yang
Download or read book Nuclear-Cytoplasmic Transport written by Weidong Yang. This book was released on 2018-07-27. Available in PDF, EPUB and Kindle. Book excerpt: Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.
Author : Marco Bacci
Release : 2014
Genre :
Kind : eBook
Book Rating : 173/5 ( reviews)
Book Synopsis Coarse-grained molecular dynamics and continuum models for the transport of protein molecules by : Marco Bacci
Download or read book Coarse-grained molecular dynamics and continuum models for the transport of protein molecules written by Marco Bacci. This book was released on 2014. Available in PDF, EPUB and Kindle. Book excerpt: The present work makes use of coarse-grained molecular dynamics simulations and continuum models to investigate the behavior of biomolecules in experiments such as mechanical pulling and driven transport across nanopores. The approach reproduces the wide phenomenology of experiments and allows one to maintain the main features of the transport by modeling the process as a 1D dynamics in a suited potential of the mean force. The standard 1D continuum view is enriched by proposing a model for the description of the shape of isolated molecules based on a tensorial representation and Cauchy-Born rule. Results indicate limitations for unconstrained dynamics and appropriateness for driven ones.
