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Clinical Concerns of Immunogenicity Produced by Biopharmaceuticals

2010-09
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Release : 2010-09
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Kind : eBook
Book Rating : 008/5 ( reviews)

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Book Synopsis Clinical Concerns of Immunogenicity Produced by Biopharmaceuticals by : Tamilvanan Shunmugaperumal

Download or read book Clinical Concerns of Immunogenicity Produced by Biopharmaceuticals written by Tamilvanan Shunmugaperumal. This book was released on 2010-09. Available in PDF, EPUB and Kindle. Book excerpt: Following the administration of biopharmaceuticals into human body, the formation of antidrug or neutralizing antibodies and other general immune system effects (including allergy, anaphylaxis, or serum sickness) are of clinical concerns regarding therapeutic efficacy and patient safety. For example, drug-induced neutralizing antibodies to erythropoietin (EPO) result in pure red cell aplasia, whereas drug-induced/acquired anti-factor VIII antibodies worsen the pathology associated with hemophilia. The possible mechanism, prediction and reduction of immunogenicity produced by biopharmaceuticals are overviewed. This book encompasses the clinical concerns of immunogenicity produced by various biopharmaceuticals such as growth hormone, insulins, granulocyte-macrophage colony-stimulating factor, interferons, megakaryocyte differentiation and growth factor, EPO, factor VIII, factor IX, acid alpha-glucosidase and glatiramer acetate including their biosimilar versions wherever possible. With this coverage of very interesting informations, this book is an essential reference for researchers in pharmaceutical industry who develop biopharmaceutical products.

Immunogenicity of Biopharmaceuticals

2008-02-06 Medical
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Release : 2008-02-06
Genre : Medical
Kind : eBook
Book Rating : 410/5 ( reviews)

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Book Synopsis Immunogenicity of Biopharmaceuticals by : Marco Weert

Download or read book Immunogenicity of Biopharmaceuticals written by Marco Weert. This book was released on 2008-02-06. Available in PDF, EPUB and Kindle. Book excerpt: Immunogenicity of Biopharmaceuticals is the first book to comprehensively address the potential of an immune response to biopharmaceuticals. It is intended to give a broad overview of the current state-of-the-art regarding this subject. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.

Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition

2012-01-09 Medical
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Release : 2012-01-09
Genre : Medical
Kind : eBook
Book Rating : 428/5 ( reviews)

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Book Synopsis Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition by :

Download or read book Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition written by . This book was released on 2012-01-09. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Adverse Reactions to Biologics

2017-11-07 Medical
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Release : 2017-11-07
Genre : Medical
Kind : eBook
Book Rating : 018/5 ( reviews)

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Book Synopsis Adverse Reactions to Biologics by : L. Puig

Download or read book Adverse Reactions to Biologics written by L. Puig. This book was released on 2017-11-07. Available in PDF, EPUB and Kindle. Book excerpt: In many areas of medicine physicians still face the great challenge of finding therapies that will meet the patients’ needs. In dermatology the challenge has arisen on multiple fronts through advances in the understanding of the immunopathogenesis of many inflammatory and malignant cutaneous disorders. Breakthroughs, combined with significant developments in targeted immunotherapy, have resulted in improved outcomes as these newer therapies are being used for both approved indications and as off-label therapies for various chronic inflammatory skin disorders and many forms of skin cancer. In the expectation that by truly understanding the safety profile of these targeted therapies patients’ outcomes will be significantly improved, this book offers insights into topics such as adverse reactions, infectious complications and the perioperative use of biologics in psoriasis, immunogenicity of biologic therapies, paradoxical reactions, safety of biologics used to treat autoimmune bullous diseases and primary cutaneous lymphomas, adverse reactions and skin manifestations of therapies targeting melanoma and non-melanoma skin cancer and other neoplastic diseases. Eminent researchers with extensive clinical experience have contributed to this publication, providing an in-depth overview of the latest knowledge in this field.

Statistical Methods for Immunogenicity Assessment

2015-07-17 Mathematics
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Release : 2015-07-17
Genre : Mathematics
Kind : eBook
Book Rating : 357/5 ( reviews)

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Book Synopsis Statistical Methods for Immunogenicity Assessment by : Harry Yang

Download or read book Statistical Methods for Immunogenicity Assessment written by Harry Yang. This book was released on 2015-07-17. Available in PDF, EPUB and Kindle. Book excerpt: Develop Effective Immunogenicity Risk Mitigation StrategiesImmunogenicity assessment is a prerequisite for the successful development of biopharmaceuticals, including safety and efficacy evaluation. Using advanced statistical methods in the study design and analysis stages is therefore essential to immunogenicity risk assessment and mitigation stra

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