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Book Synopsis Characterizing the Mechanism of Continued Primer Synthesis at Stalled Replication Forks and Its Contribution to Checkpoint Activation by :
Download or read book Characterizing the Mechanism of Continued Primer Synthesis at Stalled Replication Forks and Its Contribution to Checkpoint Activation written by . This book was released on . Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christopher Van
Release : 2010
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Book Synopsis Characterizing the Mechanism of Continued Primer Synthesis at Stalled Replication Forks and Its Contribution to Checkpoint Activation by : Christopher Van
Download or read book Characterizing the Mechanism of Continued Primer Synthesis at Stalled Replication Forks and Its Contribution to Checkpoint Activation written by Christopher Van. This book was released on 2010. Available in PDF, EPUB and Kindle. Book excerpt: Stalled replication forks activate and are stabilized by the ATR-mediated checkpoint, but ultimately they must also recover from the arrest. While primed ssDNA is sufficient for checkpoint activation, it is still unknown how this signal is generated at a stalled replication fork. Furthermore, it is not clear how recovery and fork restart occur in higher eukaryotes. Using Xenopus egg extracts, we show that DNA replication continues at a stalled fork through the synthesis and elongation of new primers independent of the checkpoint. This synthesis is dependent on the activity of PCNA, Pol[delta] and Pol[epsilon], and it contributes to the phosphorylation of Chk1. We also used defined DNA structures to show that for a fixed amount of ssDNA, increasing the number of primer-template junctions strongly enhances Chk1 phosphorylation. These results suggest that new primers are synthesized at stalled replication forks by the leading and lagging strand polymerases and that accumulation of these primers may contribute to checkpoint activation.
Author : Eishi Noguchi
Release : 2018-04-27
Genre : Science
Kind : eBook
Book Rating : 729/5 ( reviews)
Book Synopsis DNA Replication Controls: Volume 2 by : Eishi Noguchi
Download or read book DNA Replication Controls: Volume 2 written by Eishi Noguchi. This book was released on 2018-04-27. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "DNA Replication Controls" that was published in Genes
Author : Melvin DePamphilis
Release : 2010-10-06
Genre : Science
Kind : eBook
Book Rating : 231/5 ( reviews)
Book Synopsis Genome Duplication by : Melvin DePamphilis
Download or read book Genome Duplication written by Melvin DePamphilis. This book was released on 2010-10-06. Available in PDF, EPUB and Kindle. Book excerpt: Genome Duplication provides a comprehensive and readable overview of the underlying principles that govern genome duplication in all forms of life, from the simplest cell to the most complex multicellular organism. Using examples from the three domains of life - bacteria, archaea, and eukarya - Genome Duplication shows how all living organisms store their genome as DNA and how they all use the same evolutionary-conserved mechanism to duplicate it: semi-conservative DNA replication by the replication fork. The text shows how the replication fork determines where organisms begin genome duplication, how they produce a complete copy of their genome each time a cell divides, and how they link genome duplication to cell division. Genome Duplication explains how mistakes in genome duplication are associated with genetic disorders and cancer, and how understanding genome duplication, its regulation, and how the mechanisms differ between different forms of life, is critical to the understanding and treatment of human disease.
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Release : 2002
Genre : Dissertations, Academic
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Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by . This book was released on 2002. Available in PDF, EPUB and Kindle. Book excerpt:
