Cellular Trafficking of Cell Stress Proteins in Health and Disease

2012-11-19 Medical

Author : Brian Henderson
Release : 2012-11-19
Genre : Medical
Kind : eBook
Book Rating : 403/5 ( reviews)

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Book Synopsis Cellular Trafficking of Cell Stress Proteins in Health and Disease by : Brian Henderson

Download or read book Cellular Trafficking of Cell Stress Proteins in Health and Disease written by Brian Henderson. This book was released on 2012-11-19. Available in PDF, EPUB and Kindle. Book excerpt: Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.

Cellular Trafficking of Cell Stress Proteins in Health and Disease

2012-11-20 Medical

Author : Brian Henderson
Release : 2012-11-20
Genre : Medical
Kind : eBook
Book Rating : 418/5 ( reviews)

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Book Synopsis Cellular Trafficking of Cell Stress Proteins in Health and Disease by : Brian Henderson

Download or read book Cellular Trafficking of Cell Stress Proteins in Health and Disease written by Brian Henderson. This book was released on 2012-11-20. Available in PDF, EPUB and Kindle. Book excerpt: Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.

Endoplasmic Reticulum Stress in Health and Disease

2012-08-13 Medical

Author : Patrizia Agostinis
Release : 2012-08-13
Genre : Medical
Kind : eBook
Book Rating : 513/5 ( reviews)

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Book Synopsis Endoplasmic Reticulum Stress in Health and Disease by : Patrizia Agostinis

Download or read book Endoplasmic Reticulum Stress in Health and Disease written by Patrizia Agostinis. This book was released on 2012-08-13. Available in PDF, EPUB and Kindle. Book excerpt: The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.

The Unfolded Protein Response and Cellular Stress, Part A

2011-01-22 Science

Author : P. Michael Conn
Release : 2011-01-22
Genre : Science
Kind : eBook
Book Rating : 173/5 ( reviews)

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Book Synopsis The Unfolded Protein Response and Cellular Stress, Part A by : P. Michael Conn

Download or read book The Unfolded Protein Response and Cellular Stress, Part A written by P. Michael Conn. This book was released on 2011-01-22. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. - This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation - The authors explain how these methods are able to provide important biological insights

Cellular Endocrinology in Health and Disease

2021-02-19 Science

Author : Alfredo Ulloa-Aguirre
Release : 2021-02-19
Genre : Science
Kind : eBook
Book Rating : 01X/5 ( reviews)

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Book Synopsis Cellular Endocrinology in Health and Disease by : Alfredo Ulloa-Aguirre

Download or read book Cellular Endocrinology in Health and Disease written by Alfredo Ulloa-Aguirre. This book was released on 2021-02-19. Available in PDF, EPUB and Kindle. Book excerpt: Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field

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Cellular Trafficking of Cell Stress Proteins in Health and Disease

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