1# Library to Find Best eBook for Read
Author : Ying Yuan
Release : 2015-12-22
Genre : Bayesian statistical decision theory
Kind : eBook
Book Rating : 552/5 ( reviews)
Book Synopsis Bayesian Designs for Phase I-II Clinical Trials by : Ying Yuan
Download or read book Bayesian Designs for Phase I-II Clinical Trials written by Ying Yuan. This book was released on 2015-12-22. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 14: Optimizing Sedative Dose in Preterm Infants -- Bibliography -- Back Cover
Author : Scott M. Berry
Release : 2010-07-19
Genre : Mathematics
Kind : eBook
Book Rating : 513/5 ( reviews)
Book Synopsis Bayesian Adaptive Methods for Clinical Trials by : Scott M. Berry
Download or read book Bayesian Adaptive Methods for Clinical Trials written by Scott M. Berry. This book was released on 2010-07-19. Available in PDF, EPUB and Kindle. Book excerpt: Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer's disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adapti
Author : Guosheng Yin
Release : 2013-06-07
Genre : Medical
Kind : eBook
Book Rating : 320/5 ( reviews)
Book Synopsis Clinical Trial Design by : Guosheng Yin
Download or read book Clinical Trial Design written by Guosheng Yin. This book was released on 2013-06-07. Available in PDF, EPUB and Kindle. Book excerpt: A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.
Author : Wei Zhong
Release : 2012
Genre :
Kind : eBook
Book Rating : /5 ( reviews)
Book Synopsis Bayesian Adaptive Designs in Phase I/II Clinical Trials by : Wei Zhong
Download or read book Bayesian Adaptive Designs in Phase I/II Clinical Trials written by Wei Zhong. This book was released on 2012. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Timothy A. Yap
Release : 2020-09-16
Genre : Medical
Kind : eBook
Book Rating : 820/5 ( reviews)
Book Synopsis Phase I Oncology Drug Development by : Timothy A. Yap
Download or read book Phase I Oncology Drug Development written by Timothy A. Yap. This book was released on 2020-09-16. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed review of how oncology drug development has changed over the past decade, and serves as a comprehensive guide for the practicalities in setting up phase I trials. The book covers strategies to accelerate the development of novel antitumor compounds from the laboratory to clinical trials and beyond through the use of innovative mechanism-of-action pharmacodynamic biomarkers and pharmacokinetic studies. The reader will learn about all aspects of modern phase I trial designs, including the incorporation of precision medicine strategies, and approaches for rational patient allocation to novel anticancer therapies. Circulating biomarkers to assess mechanisms of response and resistance are changing the way we are assessing patient selection and are also covered in this book. The development of the different classes of antitumor agents are discussed, including chemotherapy, molecularly targeted agents, immunotherapies and also radiotherapy. The authors also discuss the lessons that the oncology field has learnt from the development of hematology-oncology drugs and how such strategies can be carried over into therapies for solid tumors. There is a dedicated chapter that covers the specialized statistical approaches necessary for phase I trial designs, including novel Bayesian strategies for dose escalation. This volume is designed to help clinicians better understand phase I clinical trials, but would also be of use to translational researchers (MDs and PhDs), and drug developers from academia and industry interested in cancer drug development. It could also be of use to phase I trial study coordinators, oncology nurses and advanced practice providers. Other health professionals interested in the treatment of cancer will also find this book of great value.
