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Autophagy and Senescence in Cancer Therapy

2021-04-13 Medical
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Release : 2021-04-13
Genre : Medical
Kind : eBook
Book Rating : 594/5 ( reviews)

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Book Synopsis Autophagy and Senescence in Cancer Therapy by :

Download or read book Autophagy and Senescence in Cancer Therapy written by . This book was released on 2021-04-13. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more. Addresses the relationship between autophagy and senescence in cancer therapy Covers autophagy and senescence in tumor dormancy Explores autophagy and senescence in disease recurrence

Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy

2018-02-19
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Release : 2018-02-19
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Kind : eBook
Book Rating : 223/5 ( reviews)

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Book Synopsis Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy by : Patrizia Agostinis

Download or read book Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy written by Patrizia Agostinis. This book was released on 2018-02-19. Available in PDF, EPUB and Kindle. Book excerpt: Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An impressive number of studies over the past decade have unraveled the plastic role of autophagy during tumor development and dissemination. The discoveries that autophagy may either support or repress neoplastic growth and contextually favor or weaken resistance and impact antitumor immunity have spurred efforts from many laboratories trying to conceptualize the complex role of autophagy in cancer using cellular and preclinical models. This complexity is further accentuated by recent findings highlighting that various autophagy-related genes have roles beyond this catabolic mechanism and interface with oncogenic pathways, other trafficking and degradation mechanisms and the cell death machinery. From a therapeutic perspective, knowledge of how autophagy modulates the tumor microenvironment is crucial to devise autophagy-targeting strategies using smart combination of drugs or anticancer modalities. This eBook contains a collection of reviews by autophagy researchers and provides a background to the state-of-the-art in the field of autophagy in cancer, focusing on various aspects of autophagy regulation ranging from its molecular components to its cell autonomous role, e.g. in cell division and oncogenesis, miRNAs regulation, cross-talk with cell death pathways as well as cell non-autonomous role, e.g. in secretion, interface with tumor stroma and clinical prospects of autophagy-based biomarkers and autophagy modulators in anticancer therapy. This eBook is part of the TransAutophagy initiative to better understand the clinical implications of autophagy in cancer.

Targeting autophagy in cancer therapy: Focus on small-molecule modulators and new strategies

2023-04-17 Science
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Release : 2023-04-17
Genre : Science
Kind : eBook
Book Rating : 746/5 ( reviews)

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Book Synopsis Targeting autophagy in cancer therapy: Focus on small-molecule modulators and new strategies by : Chen Yi

Download or read book Targeting autophagy in cancer therapy: Focus on small-molecule modulators and new strategies written by Chen Yi. This book was released on 2023-04-17. Available in PDF, EPUB and Kindle. Book excerpt:

Apoptosis, Senescence and Cancer

2007-10-23 Medical
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Release : 2007-10-23
Genre : Medical
Kind : eBook
Book Rating : 211/5 ( reviews)

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Book Synopsis Apoptosis, Senescence and Cancer by : David A. Gewirtz

Download or read book Apoptosis, Senescence and Cancer written by David A. Gewirtz. This book was released on 2007-10-23. Available in PDF, EPUB and Kindle. Book excerpt: This book provides insight into established practices and research into apoptosis and senescence. The volume thoroughly examines novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics that still hold mysteries for researchers. In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.

Modulation of Autophagy and Senescence to Enhance the Response to Therapy in Triple Negative Breast Cancer

2019
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Release : 2019
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Book Synopsis Modulation of Autophagy and Senescence to Enhance the Response to Therapy in Triple Negative Breast Cancer by : Liliya Tyutyunyk-Massey

Download or read book Modulation of Autophagy and Senescence to Enhance the Response to Therapy in Triple Negative Breast Cancer written by Liliya Tyutyunyk-Massey. This book was released on 2019. Available in PDF, EPUB and Kindle. Book excerpt: Abstract Although great strides have been made over the decades in development and optimization of anti-cancer therapies, even highly effective drugs often fail to completely eliminate tumors. Residual tumor cells can enter into a state of dormancy for prolonged periods of time but eventually are able to regain proliferative capacity and reemerge as chemotherapy-resistant disease. Because recurrent disease is a leading contributor to patient's mortality, it is paramount to identify strategies for effectively destroying residual tumor cells. Cytotoxic drugs and ionizing radiation are used as standard therapies in a variety of cancers. These modalities induce apoptosis, autophagy and senescence. Senescence is a state of prolonged growth arrest, which cells are able to eventually escape regaining proliferative capacity. Autophagy is generally considered to be a protective mechanism; however, it can take non-protective or even cytotoxic form in response to anti-cancer treatments. Furthermore, chemotherapy or radiation induced autophagy was shown to be a contributor to the immune response against tumor cells. Using a model of Triple Negative Breast Cancer, we were able to show increased immunosurveillance of tumor cells after enhanced autophagy was achieved by combining epigenetic remodeling with chemotherapy. Alternatively, we were able to achieved effective clearance of tumor cells induced into senescence by chemotherapy or radiation by the senolytic drug ABT-263 (Navitoclax). In summary, autophagy and senescence alone or in concert, can be induced by conventional anti-tumor modalities. Those processes can be modulated independently to achieve clearance of residual tumor cells following anti-cancer therapies.

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