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Applications of high-resolution mass spectrometry in drug discovery and development

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Author :
Release : 2014
Genre :
Kind : eBook
Book Rating : 562/5 ( reviews)

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Book Synopsis Applications of high-resolution mass spectrometry in drug discovery and development by :

Download or read book Applications of high-resolution mass spectrometry in drug discovery and development written by . This book was released on 2014. Available in PDF, EPUB and Kindle. Book excerpt:

Mass Spectrometry for Drug Discovery and Drug Development

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Author :
Release : 2012-12-12
Genre : Science
Kind : eBook
Book Rating : 141/5 ( reviews)

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Book Synopsis Mass Spectrometry for Drug Discovery and Drug Development by : Walter A. Korfmacher

Download or read book Mass Spectrometry for Drug Discovery and Drug Development written by Walter A. Korfmacher. This book was released on 2012-12-12. Available in PDF, EPUB and Kindle. Book excerpt: Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC high-resolution mass spectrometry for quantitative assays Mass spectrometry for siRNA Quantitative analysis of peptides Mass spectrometry analysis of biological drugs Applications that support medicinal chemistry investigations Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.

Mass Spectrometry in Drug Metabolism and Disposition

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Release : 2011-03-16
Genre : Science
Kind : eBook
Book Rating : 697/5 ( reviews)

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Book Synopsis Mass Spectrometry in Drug Metabolism and Disposition by : Mike S. Lee

Download or read book Mass Spectrometry in Drug Metabolism and Disposition written by Mike S. Lee. This book was released on 2011-03-16. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.

High-Throughput Mass Spectrometry in Drug Discovery

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Author :
Release : 2023-06-29
Genre : Science
Kind : eBook
Book Rating : 463/5 ( reviews)

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Book Synopsis High-Throughput Mass Spectrometry in Drug Discovery by : Chang Liu

Download or read book High-Throughput Mass Spectrometry in Drug Discovery written by Chang Liu. This book was released on 2023-06-29. Available in PDF, EPUB and Kindle. Book excerpt: High-Throughput Mass Spectrometry in Drug Discovery Apply mass spectrometry to every phase of new drug discovery with this cutting-edge guide Mass spectrometry is a technique that identifies and characterizes compounds based on their mass — the fundamental molecular characteristic. It has become an invaluable analytical tool in various disciplines, industries, and research fields. It has become particularly central to new drug discovery and development, which broadly deploys mass spectrometry at every phase. The pharmaceutical industry has become one of the main drivers of technological development in mass spectrometry. High-Throughput Mass Spectrometry in Drug Discovery offers a comprehensive introduction to mass spectrometry and its applications in pharmaceutical discovery. It covers the foundational principles and science of mass spectrometry before moving to specific experimental methods and their applications at various stages of drug discovery. Its thorough treatment and detailed guidance make it an invaluable tool for pharmaceutical research and development. High-Throughput Mass Spectrometry in Drug Discovery readers will also find: Detailed analysis of techniques, including label-free screening, synthetic reaction optimization, and more An authorial team with extensive combined experience in research and industrial applications Technical strategies with the potential to accelerate quantitative bioanalysis in drug discovery High-Throughput Mass Spectrometry in Drug Discovery is essential for analytical, bioanalytical, and medicinal chemists working in the pharmaceutical industry and for any researchers and graduate students interested in drug discovery and development.

Mass Spectrometry in Medicinal Chemistry

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Release : 2007-06-27
Genre : Science
Kind : eBook
Book Rating : 91X/5 ( reviews)

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Book Synopsis Mass Spectrometry in Medicinal Chemistry by : Klaus Wanner

Download or read book Mass Spectrometry in Medicinal Chemistry written by Klaus Wanner. This book was released on 2007-06-27. Available in PDF, EPUB and Kindle. Book excerpt: This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.

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