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Health Risks of Radon and Other Internally Deposited Alpha-Emitters

1988-02-01 Science
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Release : 1988-02-01
Genre : Science
Kind : eBook
Book Rating : 891/5 ( reviews)

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Book Synopsis Health Risks of Radon and Other Internally Deposited Alpha-Emitters by : National Research Council

Download or read book Health Risks of Radon and Other Internally Deposited Alpha-Emitters written by National Research Council. This book was released on 1988-02-01. Available in PDF, EPUB and Kindle. Book excerpt: This book describes hazards from radon progeny and other alpha-emitters that humans may inhale or ingest from their environment. In their analysis, the authors summarize in one document clinical and epidemiological evidence, the results of animal studies, research on alpha-particle damage at the cellular level, metabolic pathways for internal alpha-emitters, dosimetry and microdosimetry of radionuclides deposited in specific tissues, and the chemical toxicity of some low-specific-activity alpha-emitters. Techniques for estimating the risks to humans posed by radon and other internally deposited alpha-emitters are offered, along with a discussion of formulas, models, methods, and the level of uncertainty inherent in the risk estimates.

Alpha Particle Emitters in Medicine

1989
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Release : 1989
Genre :
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Alpha Particle Emitters in Medicine by :

Download or read book Alpha Particle Emitters in Medicine written by . This book was released on 1989. Available in PDF, EPUB and Kindle. Book excerpt: Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 (211At) and natural bismuth-212 (212Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 (223Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs.

MIRD: Radionuclide Data and Decay Schemes

2007 Decay schemes (Radioactivity)
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Release : 2007
Genre : Decay schemes (Radioactivity)
Kind : eBook
Book Rating : 802/5 ( reviews)

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Book Synopsis MIRD: Radionuclide Data and Decay Schemes by : Keith F. Eckerman

Download or read book MIRD: Radionuclide Data and Decay Schemes written by Keith F. Eckerman. This book was released on 2007. Available in PDF, EPUB and Kindle. Book excerpt:

Targeted Radionuclide Therapy

2012-03-28 Medical
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Release : 2012-03-28
Genre : Medical
Kind : eBook
Book Rating : 260/5 ( reviews)

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Book Synopsis Targeted Radionuclide Therapy by : Tod W. Speer

Download or read book Targeted Radionuclide Therapy written by Tod W. Speer. This book was released on 2012-03-28. Available in PDF, EPUB and Kindle. Book excerpt: Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Handbook of Radiopharmaceuticals

2003-01-17 Medical
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Release : 2003-01-17
Genre : Medical
Kind : eBook
Book Rating : 604/5 ( reviews)

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Book Synopsis Handbook of Radiopharmaceuticals by : Michael J. Welch

Download or read book Handbook of Radiopharmaceuticals written by Michael J. Welch. This book was released on 2003-01-17. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field. Radiopharmaceuticals are used to detect and characterise disease processes, or normal biological function, in living cells, animals or humans. Used as tracer molecules, they map the distribution, uptake and metabolism of the molecule in clinical studies, basic research or applied research. The area of radiopharmaceuticals is expanding rapidly. The number of PET centers in the world is increasing at 20% per year, and many drug companies are utilising PET and other forms of radiopharmaceutical imaging to evaluate products. * Readers will find coverage on a number of important topics such as radionuclide production, PET and drug development, and regulations * Explains how to use radiopharmaceuticals for the diagnosis and therapy of cancer and other diseases * The editors and a majority of the contributors are from the United States

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