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Author :
Release : 1977
Genre :
Kind : eBook
Book Rating : /5 ( reviews)
Book Synopsis Acevedo V. Finkbeiner by :
Download or read book Acevedo V. Finkbeiner written by . This book was released on 1977. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Release : 1979
Genre : Law reports, digests, etc
Kind : eBook
Book Rating : /5 ( reviews)
Book Synopsis The Federal Reporter by :
Download or read book The Federal Reporter written by . This book was released on 1979. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Udo Rüb
Release : 2015-09-29
Genre : Medical
Kind : eBook
Book Rating : 85X/5 ( reviews)
Book Synopsis The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy by : Udo Rüb
Download or read book The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy written by Udo Rüb. This book was released on 2015-09-29. Available in PDF, EPUB and Kindle. Book excerpt: This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.
Author : Clévio Nóbrega
Release : 2018-02-09
Genre : Medical
Kind : eBook
Book Rating : 790/5 ( reviews)
Book Synopsis Polyglutamine Disorders by : Clévio Nóbrega
Download or read book Polyglutamine Disorders written by Clévio Nóbrega. This book was released on 2018-02-09. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.
Author : Deborah Siegel
Release : 2007-05-15
Genre : History
Kind : eBook
Book Rating : 184/5 ( reviews)
Book Synopsis Sisterhood, Interrupted by : Deborah Siegel
Download or read book Sisterhood, Interrupted written by Deborah Siegel. This book was released on 2007-05-15. Available in PDF, EPUB and Kindle. Book excerpt: Contrary to clichés about the end of feminism, Deborah Siegel argues that younger women are reliving the battles of its past, and reinventing it--with a vengeance. From feminist blogging to the popularity of the WNBA, girl culture is on the rise. A lively and compelling look back at the framing of one of the most contentious social movements of our time, Sisterhood, Interrupted exposes the key issues still at stake, outlining how a twenty-first century feminist can reconcile the personal with the political and combat long-standing inequalities that continue today.
