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A Handbook of Transcription Factors

2011-05-10 Medical
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Release : 2011-05-10
Genre : Medical
Kind : eBook
Book Rating : 69X/5 ( reviews)

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Book Synopsis A Handbook of Transcription Factors by : Timothy R. Hughes

Download or read book A Handbook of Transcription Factors written by Timothy R. Hughes. This book was released on 2011-05-10. Available in PDF, EPUB and Kindle. Book excerpt: Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.

A Handbook of Transcription Factors

2011-05-26 Medical
Download A Handbook of Transcription Factors PDF Online Free

Author :
Release : 2011-05-26
Genre : Medical
Kind : eBook
Book Rating : 706/5 ( reviews)

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Book Synopsis A Handbook of Transcription Factors by : Timothy R. Hughes

Download or read book A Handbook of Transcription Factors written by Timothy R. Hughes. This book was released on 2011-05-26. Available in PDF, EPUB and Kindle. Book excerpt: Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.

Handbook of Transcription Factor NF-kappaB

2006-10-20 Medical
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Release : 2006-10-20
Genre : Medical
Kind : eBook
Book Rating : 271/5 ( reviews)

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Book Synopsis Handbook of Transcription Factor NF-kappaB by : Sankar Ghosh

Download or read book Handbook of Transcription Factor NF-kappaB written by Sankar Ghosh. This book was released on 2006-10-20. Available in PDF, EPUB and Kindle. Book excerpt: Recent evidence proving the molecular link between unchecked, chronic inflammation and cancer has implicated the transcription factor NF-kB as a key factor in both inhibiting apoptosis and promoting cell proliferation. Since its initial identification 20 years ago as a simple regulating factor in one small part of the immune response, NF-kB is prov

Transcription Factors and Human Disease

1998 Health & Fitness
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Release : 1998
Genre : Health & Fitness
Kind : eBook
Book Rating : 399/5 ( reviews)

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Book Synopsis Transcription Factors and Human Disease by : Gregg L. Semenza

Download or read book Transcription Factors and Human Disease written by Gregg L. Semenza. This book was released on 1998. Available in PDF, EPUB and Kindle. Book excerpt: Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that participate in specific physiologic responses. Transcription Factors and Human Disease presents the basic science of transcriptional regulation and then describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites. The involvement of transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is briefly discussed. The effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis are also explored. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.

Eukaryotic Transcription Factors

1995 Medical
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Release : 1995
Genre : Medical
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Eukaryotic Transcription Factors by : David S. Latchman

Download or read book Eukaryotic Transcription Factors written by David S. Latchman. This book was released on 1995. Available in PDF, EPUB and Kindle. Book excerpt: "Understanding the mechanisms of eukaryotic gene regulation is essential for students and scientists working in a wide range of clinical and basic disciplines. However, keeping track of the vast number of transcription factors which are central to gene regulation can prove daunting. The fourth edition of Eukaryotic Transcription Factors not only provides the reader with a clear and concise understanding of transcription factors but also of their vital role in the regulation of transcription in different cell types during development, in response to specific stimuli and in disease."--BOOK JACKET.

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