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Mapping and Sequencing the Human Genome

1988-01-01 Science
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Release : 1988-01-01
Genre : Science
Kind : eBook
Book Rating : 405/5 ( reviews)

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Book Synopsis Mapping and Sequencing the Human Genome by : National Research Council

Download or read book Mapping and Sequencing the Human Genome written by National Research Council. This book was released on 1988-01-01. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Next-Generation Genome Sequencing

2011-08-24 Science
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Release : 2011-08-24
Genre : Science
Kind : eBook
Book Rating : 733/5 ( reviews)

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Book Synopsis Next-Generation Genome Sequencing by : Michal Janitz

Download or read book Next-Generation Genome Sequencing written by Michal Janitz. This book was released on 2011-08-24. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading experts from industry and academia, this first single comprehensive resource addresses recent developments in next generation DNA sequencing technology and their impact on genome research, drug discovery and health care. As such, it presents a detailed comparative analysis of commercially available platforms as well as insights into alternative, emerging sequencing techniques. In addition, the book not only covers the principles of DNA sequencing techniques but also social, ethical and commercial aspects, the concept of personalized medicine and a five-year perspective of DNA sequencing.

DNA Sequencing Protocols

2001-01-10 Science
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Release : 2001-01-10
Genre : Science
Kind : eBook
Book Rating : 168/5 ( reviews)

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Book Synopsis DNA Sequencing Protocols by : Colin A Graham

Download or read book DNA Sequencing Protocols written by Colin A Graham. This book was released on 2001-01-10. Available in PDF, EPUB and Kindle. Book excerpt: Colin Graham and a team of leading investigators and expert clinical scientists update the acclaimed first edition with a collection of powerful, up-to-date PCR-based methods for DNA sequencing, many suitable for human genome sequencing and mutation detection in human disease. This second edition offers new material on automated DNA sequencers, capillary DNA sequencers, heterozygote mutation detection, web-based sequencing databases and genome sequencing sites, and the human genome project. State-of-the-art and highly practical, DNA Sequencing Protocols, 2nd Edn. constitutes an essential laboratory handbook for geneticists and molecular biologists, offering concise, easy-to-follow methods that will work and impact today's genome sequencing projects.

DNA Sequencing Protocols

2008-02-02 Science
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Release : 2008-02-02
Genre : Science
Kind : eBook
Book Rating : 103/5 ( reviews)

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Book Synopsis DNA Sequencing Protocols by : Annette M. Griffin

Download or read book DNA Sequencing Protocols written by Annette M. Griffin. This book was released on 2008-02-02. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of DNA Sequencing Protocols is to provide detailed practical procedures for the widest range of DNA sequencing meth ods, and we believe that all the vanguard techniques now being applied in this fast-evolving field are comprehensively covered. Sequencing technology has advanced at a phenomenal rate since the original methods were first described in the late 1970s and there is now a huge variety of strategies and methods that can be employed to determine the sequence of any DNA of interest. More recently, a large number of new and innovative sequencing techniques have been developed, including the use of such novel polymerases as Tag poly merase and Sequenase, the harnessing of PCR technology for linear amplification (cycle) sequencing, and the advent of automated DNA sequencers. DNA sequencing is surely one of the most important techniques in the molecular biology laboratory. Sequence analysis is providing an increasingly useful approach to the characterization of biological systems, and major multinational projects are already underway to map and sequence the entire genome of organisms, such as Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans, and Homo sapiens. Most scientists recognize the importance of DNA sequence data and perceive DNA sequencing as a valuable and indispensable aspect of their work. Recent technological advances, especially in the area of automated sequencing, have removed much of the drudg ery that was formerly associated with the technique, whereas innova tive computer software has greatly simplified the analysis and manipulation of sequence data.

Next-generation DNA Sequencing Informatics

2015 MEDICAL
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Release : 2015
Genre : MEDICAL
Kind : eBook
Book Rating : 236/5 ( reviews)

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Book Synopsis Next-generation DNA Sequencing Informatics by : Stuart M. Brown

Download or read book Next-generation DNA Sequencing Informatics written by Stuart M. Brown. This book was released on 2015. Available in PDF, EPUB and Kindle. Book excerpt: "Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making complete genome sequencing an affordable and frequently used tool for a wide variety of research applications. This book provides a thorough introduction to the necessary informatics methods and tools for operating NGS instruments and analyzing NGS data"

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