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Unraveling Neurodegeneration: Insights from the Drosophila Model

2023-10-03
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Release : 2023-10-03
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Book Rating : 494/5 ( reviews)

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Book Synopsis Unraveling Neurodegeneration: Insights from the Drosophila Model by : 1st Veer Bhan, 1st

Download or read book Unraveling Neurodegeneration: Insights from the Drosophila Model written by 1st Veer Bhan, 1st. This book was released on 2023-10-03. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative illnesses like Alzheimer's, Parkinson's, and ALS are devastatingconditions without cures. As populations age, these diseases are rising globally, creating anurgent need for insights into their mechanisms and treatments. The common fruit flyDrosophila melanogaster has emerged as a remarkably versatile model system to studyneurodegeneration. With a complex yet accessible nervous system, ease of geneticmanipulation, and conserved disease-related genes, the fly provides a powerful platform fordissecting the intricate biology underlying these disorders.This book provides a comprehensive overview of Drosophila neurodegeneration researchspanning over four decades. It introduces the genetics and prevalence of majorneurodegenerative diseases, along with the advantages of the fly model. Detailed case studieshighlight seminal findings from Drosophila models of Alzheimer's, Parkinson's, and ALSdiseases. The book explores cellular pathways implicated in neurodegeneration, includingprotein misfolding, oxidative stress, mitochondrial dysfunction, and neuroinflammation. Itdiscusses techniques for genetic manipulation, behavioral assays, and drug screening in flies.Emerging technologies like CRISPR/Cas9 genome editing are enabling new horizons.Importantly, the book examines therapeutic approaches informed by fly studies, such asTargeting neuroprotective genes and disease-modifying factors. It also covers ethicalconsiderations around animal research and the need for thoughtful public engagement. Thebook concludes by underscoring unanswered questions and future research directions, whileemphasizing the importance of collaborative, translational research in bringing treatmentsfrom bench to bedside.

Insights into Human Neurodegeneration: Lessons Learnt from Drosophila

2019-12-05 Medical
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Release : 2019-12-05
Genre : Medical
Kind : eBook
Book Rating : 18X/5 ( reviews)

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Book Synopsis Insights into Human Neurodegeneration: Lessons Learnt from Drosophila by : Mousumi Mutsuddi

Download or read book Insights into Human Neurodegeneration: Lessons Learnt from Drosophila written by Mousumi Mutsuddi. This book was released on 2019-12-05. Available in PDF, EPUB and Kindle. Book excerpt: This book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimer's, Parkinson’s, Spinomuscular Atrophy, Huntington’s diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders.

Unraveling the Role of Tyrosyl- and Glycyl-tRNA Synthetases in Neurodegeneration

2015
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Release : 2015
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Book Synopsis Unraveling the Role of Tyrosyl- and Glycyl-tRNA Synthetases in Neurodegeneration by : Biljana Ermanoska

Download or read book Unraveling the Role of Tyrosyl- and Glycyl-tRNA Synthetases in Neurodegeneration written by Biljana Ermanoska. This book was released on 2015. Available in PDF, EPUB and Kindle. Book excerpt:

Parkinson's Disease: Insights from Drosophila Model

2018 Technology
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Release : 2018
Genre : Technology
Kind : eBook
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Book Synopsis Parkinson's Disease: Insights from Drosophila Model by : Mohamad Ayajuddin

Download or read book Parkinson's Disease: Insights from Drosophila Model written by Mohamad Ayajuddin. This book was released on 2018. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) is a medical condition that has been known since ancient times. It is the second most common neurodegenerative disorder affecting approximately 1% of the population over 50 years. It is characterized by both motor and non-motor symptoms. Most of PD cases are sporadic while 5-10% cases are familial. Environment factors such as exposure to pesticides, herbicides and other heavy metals are expected to be the main cause of sporadic form of the disease. Mutation of the susceptible genes such as SNCA, PINK1, PARKIN, DJ1, and others are considered to be the main cause of the familial form of disease. Drosophila offers many advantages for studying human neurodegenerative diseases and their underlying molecular and cellular pathology. Shorter life span; large number of progeny; conserved molecular mechanism(s) among fly, mice and human; availability of many techniques, and tools to manipulate gene expression makes drosophila a potential model system to understand the pathology associated with PD and to unravel underlying molecular mechanism(s) responsible for dopaminergic neurodegeneration in PD-understanding of which will be of potential assistance to develop therapeutic strategies to PD. In the present review, we made an effort to discuss the contribution of fly model to understand pathophysiology of PD, in understanding the biological functions of genes implicated in PD; to understand the gene-environment interaction in PD; and validation of clues that are generated through genome-wide association studies (GWAS) in human through fly; further to screen and develop potential therapeutic molecules for PD. In nutshell, fly has been a great model system which has immensely contributed to the biomedical research relating to understand and addressing the pathology of human neurological diseases in general and PD in particular.

Drosophila: A Toolbox for the Study of Neurodegenerative Disease

2020-11-25 Science
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Release : 2020-11-25
Genre : Science
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Book Rating : 534/5 ( reviews)

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Book Synopsis Drosophila: A Toolbox for the Study of Neurodegenerative Disease by : Amritpal Mudher

Download or read book Drosophila: A Toolbox for the Study of Neurodegenerative Disease written by Amritpal Mudher. This book was released on 2020-11-25. Available in PDF, EPUB and Kindle. Book excerpt: Drosophila gives an overview of the ways in which Drosophila is currently being used as a model organism to further our understanding of a spectrum of human neurological diseases. Each chapter is written by respected researchers and gives an excellent account of the subject that is suitable for postgraduate and postdoctoral researchers.

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