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The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment

2014-04-08 Health & Fitness
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Release : 2014-04-08
Genre : Health & Fitness
Kind : eBook
Book Rating : 658/5 ( reviews)

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Book Synopsis The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment by : Jessica Wapner

Download or read book The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment written by Jessica Wapner. This book was released on 2014-04-08. Available in PDF, EPUB and Kindle. Book excerpt: One of The Wall Street Journal’s 10 Best Nonfiction Books of the Year Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

Telomeres and Telomerase in Cancer

2009-03-18 Medical
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Release : 2009-03-18
Genre : Medical
Kind : eBook
Book Rating : 796/5 ( reviews)

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Book Synopsis Telomeres and Telomerase in Cancer by : Keiko Hiyama

Download or read book Telomeres and Telomerase in Cancer written by Keiko Hiyama. This book was released on 2009-03-18. Available in PDF, EPUB and Kindle. Book excerpt: Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.

Magic Cancer Bullet

2003-06-03 Business & Economics
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Release : 2003-06-03
Genre : Business & Economics
Kind : eBook
Book Rating : 304/5 ( reviews)

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Book Synopsis Magic Cancer Bullet by : Daniel Vasella, M.D.

Download or read book Magic Cancer Bullet written by Daniel Vasella, M.D.. This book was released on 2003-06-03. Available in PDF, EPUB and Kindle. Book excerpt: History of the breakthrough of the cancer pill "Gleevec."

Wall Disease: The Psychological Toll of Living Up Against a Border

2020-10-06 Social Science
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Release : 2020-10-06
Genre : Social Science
Kind : eBook
Book Rating : 354/5 ( reviews)

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Book Synopsis Wall Disease: The Psychological Toll of Living Up Against a Border by : Jessica Wapner

Download or read book Wall Disease: The Psychological Toll of Living Up Against a Border written by Jessica Wapner. This book was released on 2020-10-06. Available in PDF, EPUB and Kindle. Book excerpt: We build border walls to keep danger out. But do we understand the danger posed by walls themselves? East Germans were the first to give the crisis a name: Mauerkrankheit, or “wall disease.” The afflicted—everyday citizens living on both sides of the Berlin wall—displayed some combination of depression, anxiety, excitability, suicidal ideation, and paranoia. The Berlin Wall is no more, but today there are at least seventy policed borders like it. What are they doing to our minds? Jessica Wapner investigates, following a trail of psychological harm around the world. In Brownsville, Texas, the hotly contested US-Mexico border wall instills more feelings of fear than of safety. And in eastern Europe, a Georgian grandfather pines for his homeland—cut off from his daughters, his baker, and his bank by the arbitrary path of a razor-wire fence built in 2013. Even in borderlands riven by conflict, the same walls that once offered relief become enduring reminders of trauma and helplessness. Our brains, Wapner writes, devote “border cells” to where we can and cannot go safely—so, a wall that goes up in our town also goes up in our minds. Weaving together interviews with those living up against walls and expert testimonies from geographers, scientists, psychologists, and other specialists, she explores the growing epidemic of wall disease—and illuminates how neither those “outside” nor “inside” are immune.

Her-2

2011-04-27 Health & Fitness
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Release : 2011-04-27
Genre : Health & Fitness
Kind : eBook
Book Rating : 982/5 ( reviews)

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Book Synopsis Her-2 by : Robert Bazell

Download or read book Her-2 written by Robert Bazell. This book was released on 2011-04-27. Available in PDF, EPUB and Kindle. Book excerpt: Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free. Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers. Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

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