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Reproducibility of Hyperpolarized Xenon-129 Magnetic Resonance Imaging

2013
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Release : 2013
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Book Synopsis Reproducibility of Hyperpolarized Xenon-129 Magnetic Resonance Imaging by : Nikhil B. E. Kanhere

Download or read book Reproducibility of Hyperpolarized Xenon-129 Magnetic Resonance Imaging written by Nikhil B. E. Kanhere. This book was released on 2013. Available in PDF, EPUB and Kindle. Book excerpt: Spirometry and plethysmography provide gold standard measurements of obstructive lung disease, although these are global measurements of lung function made at the mouth, of a highly regionally heterogeneous disease. Hyperpolarized 129Xe magnetic resonance imaging (MRI) is a non-invasive, non-radiation-based imaging tool for visualizing regional lung structure and function. However, the reproducibility of 129Xe MRI measurements has not yet been studied or determined. Hence, in this thesis, we evaluated the reproducibility of 129Xe MRI using quantitative measurements such as ventilation defect percent (VDP). We showed that 129Xe VDP had high intra-observer and inter-observer reproducibility for repeated scans acquired on the same-day and after 1-week and its reproducibility was comparable to that of 3He VDP. 129Xe VDP showed strong and significant correlations with pulmonary function tests. These results suggested that 129Xe VDP is reproducible over short periods of time and can be a reliable measurement to study pulmonary function in imaging studies.

MRI of the Lung

2008-11-12 Medical
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Release : 2008-11-12
Genre : Medical
Kind : eBook
Book Rating : 18X/5 ( reviews)

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Book Synopsis MRI of the Lung by : Hans-Ulrich Kauczor

Download or read book MRI of the Lung written by Hans-Ulrich Kauczor. This book was released on 2008-11-12. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade significant developments have been achieved in the field of magnetic resonance imaging (MRI), enabling MRI to enter the clinical arena of chest imaging. Standard protocols can now be implemented on up-to-date scanners, allowing MRI to be used as a first-line imaging modality for various lung diseases, including cystic fibrosis, pulmonary hypertension and even lung cancer. The diagnostic benefits stem from the ability of MRI to visualize changes in lung structure while simultaneously imaging different aspects of lung function, such as perfusion, respiratory motion, ventilation and gas exchange. On this basis, novel quantitative surrogates for lung function can be obtained. This book provides a comprehensive overview of how to use MRI for imaging of lung disease. Special emphasis is placed on benign diseases requiring regular monitoring, given that it is patients with these diseases who derive the greatest benefit from the avoidance of ionizing radiation.

Pulmonary Functional Imaging

2020-12-11 Medical
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Release : 2020-12-11
Genre : Medical
Kind : eBook
Book Rating : 393/5 ( reviews)

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Book Synopsis Pulmonary Functional Imaging by : Yoshiharu Ohno

Download or read book Pulmonary Functional Imaging written by Yoshiharu Ohno. This book was released on 2020-12-11. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the basics of pulmonary functional imaging using new CT and MR techniques and describes the clinical applications of these techniques in detail. The intention is to equip readers with a full understanding of pulmonary functional imaging that will allow optimal application of all relevant techniques in the assessment of a variety of diseases, including COPD, asthma, cystic fibrosis, pulmonary thromboembolism, pulmonary hypertension, lung cancer and pulmonary nodule. Pulmonary functional imaging has been promoted as a research and diagnostic tool that has the capability to overcome the limitations of morphological assessments as well as functional evaluation based on traditional nuclear medicine studies. The recent advances in CT and MRI and in medical image processing and analysis have given further impetus to pulmonary functional imaging and provide the basis for future expansion of its use in clinical applications. In documenting the utility of state-of-the-art pulmonary functional imaging in diagnostic radiology and pulmonary medicine, this book will be of high value for chest radiologists, pulmonologists, pulmonary surgeons, and radiation technologists.

Hyperpolarized Gas MRI to Evaluate Emphysema

2008-04-01 Medical
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Release : 2008-04-01
Genre : Medical
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Book Rating : 367/5 ( reviews)

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Book Synopsis Hyperpolarized Gas MRI to Evaluate Emphysema by : Jaime Mata

Download or read book Hyperpolarized Gas MRI to Evaluate Emphysema written by Jaime Mata. This book was released on 2008-04-01. Available in PDF, EPUB and Kindle. Book excerpt: Characterized by destruction of distal parenchymal airspaces, emphysema is a good candidate for the application of new magnetic resonance (MR) diffusion imaging techniques that use hyperpolarized helium-3 (He-3) and xenon-129 (Xe-129) gases to probe the restricted diffusion of gas in the lung. Besides the importance of detecting and diagnosing emphysema at early stages, which could reduce disease severity and maximize the effectiveness of treatment, the scientific community also needs a better biomarker for emphysema with a higher sensitivity than the gold standard, pulmonary function tests, and without the ionizing radiation of computed tomography. A primary goal of this project was to create a reproducible animal model of emphysema disease, and with it demonstrate the efficacy, sensitivity and reproducibility of hyperpolarized He-3 and Xe-129 diffusion (ADC) measurements. Both He-3 and Xe-129 ADC measurements demonstrated excellent reproducibility, and strong correlations were found between these values and the distal airspace size as measured by lung morphometry. The last goal of this project was to investigate the characteristics of diffusion sensitization based on multiple bipolar gradient waveforms, which have the potential to extend access to much shorter diffusion times.

Hyperpolarized Xenon-129 Magnetic Resonance

2015-04-14 Medical
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Release : 2015-04-14
Genre : Medical
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Book Rating : 890/5 ( reviews)

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Book Synopsis Hyperpolarized Xenon-129 Magnetic Resonance by : Thomas Meersmann

Download or read book Hyperpolarized Xenon-129 Magnetic Resonance written by Thomas Meersmann. This book was released on 2015-04-14. Available in PDF, EPUB and Kindle. Book excerpt: Providing the first comprehensive book on the current state of hyperpolarized Xenon-129 NMR and MRI, this book is guaranteed to appeal to a wide range of scientists interested in this growing field. It is intended to create synergy between the various communities working with this noble gas. Covering all topics from the production of the hyperpolarized gas to its applications, the editors have invited a leading team of experts to combine the physical chemistry within the various topics and across disciplines. The scope will range from the fundamental aspects of optical pumping to practical aspects of hyperpolarizers and hp-xenon handling. The applications section will focus on hyperpolarized xenon-129 detected in the dissolved phase or micro porous media where the chemical shift of xenon-129 can be used as a diagnostic probe. Appealing to researchers in the biomedical field and materials sciences, this reference book will provide background reading and future looking material in one place.

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