1# Library to Find Best eBook for Read
Author : Javier Ramírez
Release : 2019-08-12
Genre :
Kind : eBook
Book Rating : 497/5 ( reviews)
Book Synopsis Multimodal and Longitudinal Bioimaging Methods for Characterizing the Progressive Course of Dementia by : Javier Ramírez
Download or read book Multimodal and Longitudinal Bioimaging Methods for Characterizing the Progressive Course of Dementia written by Javier Ramírez. This book was released on 2019-08-12. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sanjiv Sam Gambhir
Release : 2015
Genre :
Kind : eBook
Book Rating : /5 ( reviews)
Book Synopsis Molecular Imaging Primer by : Sanjiv Sam Gambhir
Download or read book Molecular Imaging Primer written by Sanjiv Sam Gambhir. This book was released on 2015. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Heiko Braak
Release : 2014-12-11
Genre : Medical
Kind : eBook
Book Rating : 792/5 ( reviews)
Book Synopsis Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by : Heiko Braak
Download or read book Neuroanatomy and Pathology of Sporadic Alzheimer's Disease written by Heiko Braak. This book was released on 2014-12-11. Available in PDF, EPUB and Kindle. Book excerpt: As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail
Author : Agustín Ibáñez
Release : 2018-06-21
Genre :
Kind : eBook
Book Rating : 940/5 ( reviews)
Book Synopsis Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America by : Agustín Ibáñez
Download or read book Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America written by Agustín Ibáñez. This book was released on 2018-06-21. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.
Author : M. Filippi
Release : 2012-12-06
Genre : Medical
Kind : eBook
Book Rating : 347/5 ( reviews)
Book Synopsis Primary Progressive Multiple Sclerosis by : M. Filippi
Download or read book Primary Progressive Multiple Sclerosis written by M. Filippi. This book was released on 2012-12-06. Available in PDF, EPUB and Kindle. Book excerpt: "Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin ical trials have excluded PPMS patients on two counts. Clinical worsening devel ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the ~-interferons and glatiramer acetate, preliminary, uncontrolled clinical experi ence suggests that the results may not be dramatic.
