Share

Insights into Human Neurodegeneration: Lessons Learnt from Drosophila

2019-12-05 Medical
Download Insights into Human Neurodegeneration: Lessons Learnt from Drosophila PDF Online Free

Author :
Release : 2019-12-05
Genre : Medical
Kind : eBook
Book Rating : 18X/5 ( reviews)

GET EBOOK


Book Synopsis Insights into Human Neurodegeneration: Lessons Learnt from Drosophila by : Mousumi Mutsuddi

Download or read book Insights into Human Neurodegeneration: Lessons Learnt from Drosophila written by Mousumi Mutsuddi. This book was released on 2019-12-05. Available in PDF, EPUB and Kindle. Book excerpt: This book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimer's, Parkinson’s, Spinomuscular Atrophy, Huntington’s diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders.

Life Extension

2015-06-09 Medical
Download Life Extension PDF Online Free

Author :
Release : 2015-06-09
Genre : Medical
Kind : eBook
Book Rating : 265/5 ( reviews)

GET EBOOK


Book Synopsis Life Extension by : Alexander M. Vaiserman

Download or read book Life Extension written by Alexander M. Vaiserman. This book was released on 2015-06-09. Available in PDF, EPUB and Kindle. Book excerpt: ​This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans. Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine. This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.

Unraveling Neurodegeneration: Insights from the Drosophila Model

2023-10-03
Download Unraveling Neurodegeneration: Insights from the Drosophila Model PDF Online Free

Author :
Release : 2023-10-03
Genre :
Kind : eBook
Book Rating : 494/5 ( reviews)

GET EBOOK


Book Synopsis Unraveling Neurodegeneration: Insights from the Drosophila Model by : 1st Veer Bhan, 1st

Download or read book Unraveling Neurodegeneration: Insights from the Drosophila Model written by 1st Veer Bhan, 1st. This book was released on 2023-10-03. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative illnesses like Alzheimer's, Parkinson's, and ALS are devastatingconditions without cures. As populations age, these diseases are rising globally, creating anurgent need for insights into their mechanisms and treatments. The common fruit flyDrosophila melanogaster has emerged as a remarkably versatile model system to studyneurodegeneration. With a complex yet accessible nervous system, ease of geneticmanipulation, and conserved disease-related genes, the fly provides a powerful platform fordissecting the intricate biology underlying these disorders.This book provides a comprehensive overview of Drosophila neurodegeneration researchspanning over four decades. It introduces the genetics and prevalence of majorneurodegenerative diseases, along with the advantages of the fly model. Detailed case studieshighlight seminal findings from Drosophila models of Alzheimer's, Parkinson's, and ALSdiseases. The book explores cellular pathways implicated in neurodegeneration, includingprotein misfolding, oxidative stress, mitochondrial dysfunction, and neuroinflammation. Itdiscusses techniques for genetic manipulation, behavioral assays, and drug screening in flies.Emerging technologies like CRISPR/Cas9 genome editing are enabling new horizons.Importantly, the book examines therapeutic approaches informed by fly studies, such asTargeting neuroprotective genes and disease-modifying factors. It also covers ethicalconsiderations around animal research and the need for thoughtful public engagement. Thebook concludes by underscoring unanswered questions and future research directions, whileemphasizing the importance of collaborative, translational research in bringing treatmentsfrom bench to bedside.

Altered Metabolism: A Major Contributor of Comorbidities in Neurodegenerative Diseases

Download Altered Metabolism: A Major Contributor of Comorbidities in Neurodegenerative Diseases PDF Online Free

Author :
Release :
Genre :
Kind : eBook
Book Rating : 889/5 ( reviews)

GET EBOOK


Book Synopsis Altered Metabolism: A Major Contributor of Comorbidities in Neurodegenerative Diseases by : Namita Agrawal

Download or read book Altered Metabolism: A Major Contributor of Comorbidities in Neurodegenerative Diseases written by Namita Agrawal. This book was released on . Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye

2020-05-18 Medical
Download Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye PDF Online Free

Author :
Release : 2020-05-18
Genre : Medical
Kind : eBook
Book Rating : 461/5 ( reviews)

GET EBOOK


Book Synopsis Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye by : Amit Singh

Download or read book Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye written by Amit Singh. This book was released on 2020-05-18. Available in PDF, EPUB and Kindle. Book excerpt: Drosophila melanogaster (fruit fly) is a highly versatile model with a genetic legacy of more than a century. It provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology is how a multi-cellular organism develops from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question and has led to other questions, such as the role of various genetic and cell biological pathways in regulating the process of pattern formation and growth during organogenesis. The Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This updated second edition covers current progress in the study of molecular genetic mechanisms of pattern formation, mutations in axial patterning, genetic regulation of growth, and more using the Drosophila eye as a model.

You may also like...