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Innate Immunity to Pulmonary Infection

2007-01-11 Medical
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Release : 2007-01-11
Genre : Medical
Kind : eBook
Book Rating : 382/5 ( reviews)

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Book Synopsis Innate Immunity to Pulmonary Infection by : Derek J. Chadwick

Download or read book Innate Immunity to Pulmonary Infection written by Derek J. Chadwick. This book was released on 2007-01-11. Available in PDF, EPUB and Kindle. Book excerpt: Part of the prestigious Novartis Foundation series, this volume uniquely addresses the use of innate immunity to treat or prevent infectious diseases of the lung. Innate Immunity to Pulmonary Infection: Provides a comprehensive overview of pulmonary infectious diseases, including basic pathology, current and potential therapies, and detailed consideration of the innate biological resistance mechanisms in the lung Thoroughly examines the major topic of innate immunity in immunology, which is now seen as key to the pathogenesis of and vaccination strategies for infectious diseases Describes the genetic and environmental factors which determine the outcome of infection, such as latency of Tuberculosis, blood stream invasion from local infection, and local target tissue damage Covers the roles of cells such as neutrophils, macrophages and dendritic cells and of molecular components such as Toll-like receptors Discusses the clinical applications of the new knowledge regarding innate immunity and how this can be used in both treatment and prevention (vaccination) strategies Includes contributions from an international and interdisciplinary group of experts Innate Immunity to Pulmonary Infection is an essential resource for researchers in both industry and academia. It is of interest for all those interested in the disciplines of immunology, virology, biology, biotechnology and genetics.

Molecular Biology of the Cell

2002 Cells
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Release : 2002
Genre : Cells
Kind : eBook
Book Rating : 183/5 ( reviews)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by . This book was released on 2002. Available in PDF, EPUB and Kindle. Book excerpt:

Janeway's Immunobiology

2010-06-22 Medical
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Release : 2010-06-22
Genre : Medical
Kind : eBook
Book Rating : 575/5 ( reviews)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy. This book was released on 2010-06-22. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

SARS, MERS and other Viral Lung Infections

2016-06-01 Medical
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Release : 2016-06-01
Genre : Medical
Kind : eBook
Book Rating : 709/5 ( reviews)

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Book Synopsis SARS, MERS and other Viral Lung Infections by : David S. Hui

Download or read book SARS, MERS and other Viral Lung Infections written by David S. Hui. This book was released on 2016-06-01. Available in PDF, EPUB and Kindle. Book excerpt: Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.

Cell-specific Innate Immunity in Lung Infection and Inflammation

2017
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Release : 2017
Genre :
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Book Synopsis Cell-specific Innate Immunity in Lung Infection and Inflammation by : Adam Ahmad Anas

Download or read book Cell-specific Innate Immunity in Lung Infection and Inflammation written by Adam Ahmad Anas. This book was released on 2017. Available in PDF, EPUB and Kindle. Book excerpt: "Pneumonia and asthma affect millions of adults and children annually and are responsible for a significant amount of morbidity and mortality worldwide. Our airways are continuously exposed to pathogens and allergens inhaled through air that can potentially cause these serious illnesses. The innate immune system is initiated once the epithelial barrier fails. The net effect of the innate immunity is the result of complex cell-specific responses not yet fully understood. In this thesis, we studied these cell-specific contributions to host defense using genetically modified mice in which bacterial pneumonia and asthma were simulated. Cells present in the respiratory tract are able to recognize specific molecular patterns of pathogens or allergens because of the expression Toll-like receptors (TLRs). Correct functioning of TLRs is regulated by the chaperone glycoprotein 96 (gp96), and we found that host defense of mice with gp96 deficient macrophages was strongly impaired during pneumonia caused by Klebsiella pneumoniae. Next, we studied the cell-specific role of myeloid differentiation factor 88 (MyD88), the universal adaptor protein found downstream in the TLR signaling pathway. In a series of studies, we found that only myeloid MyD88, but not endothelial or epithelial MyD88, contributes significantly to protection against Klebsiella pneumonia, while in pneumonia induced by Pseudomonas Aeruginosa, antibacterial defense depends on epithelial but not myeloid MyD88. Finally, we examined the role of cell-specific MyD88 signaling in asthma, and found that general expression of MyD88 is essential for the development of asthma. Neither myeloid nor alveolar type II MyD88 affects asthma induced inflammatory response."--Samenvatting auteur.

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