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Free Radicals in Biology and Medicine

2015 Medical
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Release : 2015
Genre : Medical
Kind : eBook
Book Rating : 474/5 ( reviews)

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Book Synopsis Free Radicals in Biology and Medicine by : Barry Halliwell

Download or read book Free Radicals in Biology and Medicine written by Barry Halliwell. This book was released on 2015. Available in PDF, EPUB and Kindle. Book excerpt: Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.

Free Radicals

2012-04-26 Science
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Release : 2012-04-26
Genre : Science
Kind : eBook
Book Rating : 713/5 ( reviews)

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Book Synopsis Free Radicals by : Michael Brooks

Download or read book Free Radicals written by Michael Brooks. This book was released on 2012-04-26. Available in PDF, EPUB and Kindle. Book excerpt: “An exuberant tour through the world of scientists behaving badly” (The New York Times). They may have a public image as cool, logical, levelheaded types. But in reality, scientists will do pretty much anything—take drugs, follow mystical visions, lie, and even cheat—to make a discovery. In Free Radicals, physicist and journalist Michael Brooks seamlessly weaves together true stories of the “mad, bad and dangerous” men and women who have revolutionized the scientific world, and offers a fast-paced and thrilling exploration of the real process behind discovery (The Times, London). Brooks also traces the cover-up back to its source: the scientific establishment’s reaction to the public fear of science after World War II. He argues that it its high time for science to come clean about just how bold and daring scientists really are. “Not all scientists are nerds. In Free Radicals, physicist Michael Brooks tries to dispel the notion that scientists are stuffy, pen-protector-polishing bookworms.” —The Washington Post “Insightful . . . A page-turning, unvarnished look at the all-too-human side of science.” —Kirkus Reviews

Free-Radical-Induced DNA Damage and Its Repair

2006-03-20 Science
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Release : 2006-03-20
Genre : Science
Kind : eBook
Book Rating : 920/5 ( reviews)

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Book Synopsis Free-Radical-Induced DNA Damage and Its Repair by : Clemens Sonntag

Download or read book Free-Radical-Induced DNA Damage and Its Repair written by Clemens Sonntag. This book was released on 2006-03-20. Available in PDF, EPUB and Kindle. Book excerpt: The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.

Handbook of Free Radical Initiators

2005-01-14 Science
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Release : 2005-01-14
Genre : Science
Kind : eBook
Book Rating : 832/5 ( reviews)

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Book Synopsis Handbook of Free Radical Initiators by : E. T. Denisov

Download or read book Handbook of Free Radical Initiators written by E. T. Denisov. This book was released on 2005-01-14. Available in PDF, EPUB and Kindle. Book excerpt: Free radical initiators–chemical molecules which easily decompose into free radicals–serve as reactive intermediates in synthetic methodologies such as organic and polymer synthesis as well as in technological processes, oligomerization, network formation, and kinetic research. The Handbook of Free Radical Initiators presents an up-to-date account of the physicochemical data on radical initiators and reactions of radical generation. Individual chapters include: Dialkyl Peroxides and Hydroperoxides Diacyl Peroxides, Peresters, and Organic Polyoxides Azo-Compounds Bimolecular Reactions of Free Radical Generation by Ozone, Dioxygen, Hydroperoxides, and Haloid Molecules Free Radical Abstraction Reactions Free Radical Addition Reactions Free Radical Recombination and Disproportoination Reactions Professionals and academic researchers in chemical engineering, pharmaceuticals, biotechnology, plastics, and rubbers will find the Handbook of Free Radical Initiators to be a distinguished, vital resource.

Free Radicals in Human Health and Disease

2014-11-14 Science
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Release : 2014-11-14
Genre : Science
Kind : eBook
Book Rating : 358/5 ( reviews)

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Book Synopsis Free Radicals in Human Health and Disease by : Vibha Rani

Download or read book Free Radicals in Human Health and Disease written by Vibha Rani. This book was released on 2014-11-14. Available in PDF, EPUB and Kindle. Book excerpt: The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.

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