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Fast Dynamic Surfactant Reduces Aggregation of Biologics

2017
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Release : 2017
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Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Fast Dynamic Surfactant Reduces Aggregation of Biologics by : Joshua S Katz

Download or read book Fast Dynamic Surfactant Reduces Aggregation of Biologics written by Joshua S Katz. This book was released on 2017. Available in PDF, EPUB and Kindle. Book excerpt: As the pharmaceutical industry shifts from small molecule drug to biologic drug development, new and unique formulation needs emerge. Issues relating to shelf-stability of biologic formulations remain a key challenge to new drug development for both the developed and developing world. N-myristoyl phenylalanine Jeffamine M1000 diamide (FM1000) is a new experimental surfactant that has been developed for stabilizing biopharmaceuticals. FM1000 exhibits an order of magnitude faster interfacial dynamics than conventional formulation excipients, leading to improved agitation stability. A three-fold drop in IgG aggregation rate was observed for IgG formulated with FM1000 compared to control surfactant formulations. In a study of abatacept aggregation, FM1000 minimized the monomer loss both in glass vials and in IV bags, even out-performing Poloxamer 188, the incumbent technology. FM1000 also reduced subvisible particle formation in a cetuximab model formulation. Coupling aggregation performance with fundamental surfactant interfacial dynamics and behavior will help better understand the underlying mechanisms of protein (de)stabilization, enabling the development of higher stability formulations.

Protein Self-Assembly

2020-08-08 Science
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Release : 2020-08-08
Genre : Science
Kind : eBook
Book Rating : 803/5 ( reviews)

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Book Synopsis Protein Self-Assembly by : Jennifer J. McManus

Download or read book Protein Self-Assembly written by Jennifer J. McManus. This book was released on 2020-08-08. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.

Interfacial Processes and Molecular Aggregation of Surfactants

2008-08-28 Technology & Engineering
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Release : 2008-08-28
Genre : Technology & Engineering
Kind : eBook
Book Rating : 108/5 ( reviews)

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Book Synopsis Interfacial Processes and Molecular Aggregation of Surfactants by : Ranga Narayanan

Download or read book Interfacial Processes and Molecular Aggregation of Surfactants written by Ranga Narayanan. This book was released on 2008-08-28. Available in PDF, EPUB and Kindle. Book excerpt: Given the enormous interest in surface phenomena in areas ranging from materials science to applications in life science, this volume is a very timely addition to the literature. Emphasis is on surfactants mediating interfacial and molecular aggregation phenomena, and the following topics are reviewed in particular: dissolution rates, equilibrium adsorption, mixing rules, and spreading on a solid surface of surfactants, as well as the role of surfactants in mediating a range of processes, such as the fabrication of various nanomaterials. Written and edited by leading experts, this volume is dedicated to Professor Dinesh O. Shah, one of the pioneers in this field.

Aggregation of Therapeutic Proteins

2010-12-28 Medical
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Release : 2010-12-28
Genre : Medical
Kind : eBook
Book Rating : 588/5 ( reviews)

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Book Synopsis Aggregation of Therapeutic Proteins by : Wei Wang

Download or read book Aggregation of Therapeutic Proteins written by Wei Wang. This book was released on 2010-12-28. Available in PDF, EPUB and Kindle. Book excerpt: This book gives pharmaceutical scientists an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. While significant progress has been made in the past decade, the current understanding of protein aggregation and its consequences is still immature. Prevention or even moderate inhibition of protein aggregation has been mostly experimental. The knowledge in this book can greatly help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this area. This book fills such a need by providing an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins.

Encyclopedia of Colloid and Interface Science

2013-06-28 Technology & Engineering
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Release : 2013-06-28
Genre : Technology & Engineering
Kind : eBook
Book Rating : 641/5 ( reviews)

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Book Synopsis Encyclopedia of Colloid and Interface Science by : Tharwat Tadros

Download or read book Encyclopedia of Colloid and Interface Science written by Tharwat Tadros. This book was released on 2013-06-28. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative and comprehensive reference relevant to all scientists and engineers in the field. This encyclopedia not only helps chemistry, materials science and physics researchers to understand the principles, but also provides practicing engineers with the necessary information for implementing practical applications, such as Food and agrochemicals Polymers and ceramics Cosmetics and detergents Paints and coatings Pharmaceuticals and drug delivery In addition, the encyclopedia is an important reference for industrial chemists and chemical engineers faced with a multitude of industrial systems of a colloidal nature. As wide as the range of applications that colloid and interface science has is the range of scientific disciplines that contribute to research and development in this field. These encompass chemistry, physics, biology and mathematics as well as nanoscience and nanotechnology. The encyclopedia provides easy-to-digest information for meeting these interdisciplinary challenges. While providing numerous concise definitions of key terms, the encyclopedia also features more than forty in-depth essays on topics ranging from Agrochemical Formulations to Zeta Potential. All entries are cross-referenced and include selected references to original literature as well as synonyms.

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